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Livermore research in accelerator mass spectrometry highlighted at ACS meeting

LIVERMORE, Calif. -- DNA damage formed during carcinogenesis is just one of the topics researchers from the Lawrence Livermore National Laboratory will discuss during the 228th National Meeting of the American Chemical Society in Philadelphia.

Paul Henderson of Livermore's Biology and Biotechnology Research Program (BBRP) will host a mini symposium titled "Emerging Applications of Accelerator Mass Spectrometry to Toxicology and Pharmacokinetics" on Sunday, Aug. 22, from 9 a.m.-noon on the biological applications of accelerator mass spectrometry (AMS). Biological research with AMS is a growing interest because os the technology's exceptional sensitivity and precision compared to more conventional types of mass spectrometry.

Karen Dingley of BBRP will present the use of AMS to detect carcinogens, called heterocyclic amines, formed during the cooking of meat and research on the prevention of cancer due to those chemicals. Her talk also will be included in Henderson's mini symposium.

Other presentations include using AMS to study new potential biomarkers for atherosclerosis, DNA oxidation in breast cancer cells, pharmacokinetics and development of novel drug delivery devices.

Henderson will present an overview of AMS applications in biological research and the use of AMS to detect a new type of DNA damage in breast cancer cells.

Charles Westbrook of the Chemistry and Materials Science (CMS) Directorate will discuss "Kinetic Modeling of Soot Production in Combustion of Munitions" at 4 p.m., Tuesday, Aug. 24.

Destroying outdated munitions is typically done by either burning or detonations in an open environment. Soot production during this destruction has become a serious problem for environmental reasons. Westbrook and colleague William Pitz have used kinetic modeling to observe the soot production chemistry involved.

The chemical kinetic models used in studying soot production during munitions destruction were orig
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Contact: Lynda Seaver or Anne M. Stark
seaver1@llnl.gov
925-423-3103
DOE/Lawrence Livermore National Laboratory
20-Aug-2004


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