HOME >> BIOLOGY >> NEWS
Location of potential familial lung cancer gene discovered

BETHESDA, Md., Mon., July 26, 2004 -- Researchers have discovered a possible inherited component for lung cancer, a disease normally associated with external causes, such as cigarette smoking. An interdisciplinary consortium consisting of 12 research institutions and universities, including the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both part of the National Institutes of Health (NIH), identified a major lung cancer susceptibility region on a segment of chromosome 6. The findings appear in a just-posted-online edition of American Journal of Human Genetics* and will appear in print in the September 2004 issue.

The Genetic Epidemiology of Lung Cancer Consortium (GELCC) ** examined 52 families who had at least three first-degree family members affected by lung, throat, or laryngeal cancer. Of these 52 families, 36 had affected members in at least two generations. Using 392 known genetic markers, which are DNA sequences that are known to be common sites of genetic variation, the researchers generated and then compared the alleles (the different variations each gene can take) of all affected and non-affected family members who were willing to participate in the study.

The researchers found strong evidence that a lung cancer susceptibility gene or genes is co-inherited with a genetic marker on chromosome 6. Markers on chromosomes 12, 14, and 20 also indicated possible linkage to lung cancer susceptibility, although the results were not as strong. Identifying the locus was a critical first step, but more work needs to be done.

"The genetic markers are like those mileage markers you see on the side of the highway," explained NCI's Jonathon Wiest, Ph.D. "They can be very useful for broad navigational purposes, but at the same time they don't give you precise information about all the interesting things that may lie along the highway."

The next goal for these researchers is to
'"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
26-Jul-2004


Page: 1 2 3

Related biology news :

1. Location of ulcerations in diabetic patients may be explained by blood flow
2. Lipoprotein lipase: Location, location, location.
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
5. Award winning researchers reveal potential new role for Glivec
6. Evidence builds for potential new cancer drug target
7. Scientists discover potential new way to control drug-resistant bacteria
8. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
9. OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
10. Managing occupational exposures to potential bioterrorist agents
11. Acamprosate: potential medication for treating alcoholism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... WASHINGTON , April 27, 2017  Kinexum, a ... science products, today announces the appointment of Thomas ... G. Alexander ("Zan") Fleming, M.D., Kinexum founder, who becomes ... strategic advisor to Kinexum clients. Thomas ... take on the Kinexum mission and lead the firm,s ...
(Date:4/26/2017)... , ... April 26, 2017 , ... ... demonstrating its new Bioflash MailGuardtm mail security screening solution at the National Postal ... Bioflash MailGuard system provides a fast, highly accurate, easy to use and low ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... supplier of Common Lisp (CL) development tools, and market leader for Semantic ... key performance enhancements now available within the most effective system for developing and ...
(Date:4/25/2017)... WA (PRWEB) , ... April 25, 2017 , ... Leaders ... division of Quorum, will be featured in multiple sessions at this week’s Association ... from emerging trends to best practices in clinical research. , "We are excited to ...
Breaking Biology Technology:
Cached News: