HOME >> BIOLOGY >> NEWS
Location of potential familial lung cancer gene discovered

BETHESDA, Md., Mon., July 26, 2004 -- Researchers have discovered a possible inherited component for lung cancer, a disease normally associated with external causes, such as cigarette smoking. An interdisciplinary consortium consisting of 12 research institutions and universities, including the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both part of the National Institutes of Health (NIH), identified a major lung cancer susceptibility region on a segment of chromosome 6. The findings appear in a just-posted-online edition of American Journal of Human Genetics* and will appear in print in the September 2004 issue.

The Genetic Epidemiology of Lung Cancer Consortium (GELCC) ** examined 52 families who had at least three first-degree family members affected by lung, throat, or laryngeal cancer. Of these 52 families, 36 had affected members in at least two generations. Using 392 known genetic markers, which are DNA sequences that are known to be common sites of genetic variation, the researchers generated and then compared the alleles (the different variations each gene can take) of all affected and non-affected family members who were willing to participate in the study.

The researchers found strong evidence that a lung cancer susceptibility gene or genes is co-inherited with a genetic marker on chromosome 6. Markers on chromosomes 12, 14, and 20 also indicated possible linkage to lung cancer susceptibility, although the results were not as strong. Identifying the locus was a critical first step, but more work needs to be done.

"The genetic markers are like those mileage markers you see on the side of the highway," explained NCI's Jonathon Wiest, Ph.D. "They can be very useful for broad navigational purposes, but at the same time they don't give you precise information about all the interesting things that may lie along the highway."

The next goal for these researchers is to
'"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
26-Jul-2004


Page: 1 2 3

Related biology news :

1. Location of ulcerations in diabetic patients may be explained by blood flow
2. Lipoprotein lipase: Location, location, location.
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
5. Award winning researchers reveal potential new role for Glivec
6. Evidence builds for potential new cancer drug target
7. Scientists discover potential new way to control drug-resistant bacteria
8. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
9. OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
10. Managing occupational exposures to potential bioterrorist agents
11. Acamprosate: potential medication for treating alcoholism

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Location potential familial lung cancer gene discovered

(Date:6/24/2015)... June 22, 2015 ... addition of the "Huawei Ascend Mate 7 ... to their offering. Huawei,s technological choice ... opposite direction than Apple,s and Samsung,s one. The ... developed by Fingerprint Cards, a main actor in ...
(Date:6/23/2015)... June 23, 2015  Crossmatch™, a leading ... today announced enhanced functionality of its DigitalPersona ... The enhancements build on the native flexibility ... Altus platform and provide expanded mobile credential ... In today,s environment of increasing cyber-attacks and ...
(Date:6/17/2015)... June 17, 2015  Synaptics Inc. (NASDAQ: ... today announced that Xiaomi, one of the world,s ... ClearPad ® family of capacitive touchscreen ... circuits (DDICs) for its latest smartphones, the Xiaomi ... for full in-cell display solutions and DDICs in ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
(Date:7/6/2015)... June 29, 2015 ... the addition of the "Biotechnology for the ... Biotechnology for the Non-Biotechnologist, ideal for non-Scientists and ... techniques and potential of biotechnology. Ideal ... basic theory, principles, techniques, and potential of biotechnology ...
(Date:7/6/2015)... , July 6, 2015 ImmunoCellular Therapeutics, Ltd. ... an agreement with Novella Clinical (Novella), to ... patients with newly diagnosed glioblastoma. Novella is a full-service, ... to small to mid-sized oncology companies. The ICT-107 phase ... the US, Europe and ...
(Date:7/3/2015)... WIEN , July 3, ... Tiedemiehet voivat hakea verkossa osoitteessa  ... for Open Innovation in Science" ... Ludwig Boltzmann Gesellschaftin (LBG) tekemän, ... tutkimuksen mukaan terveystieteiden kaksi suurinta ...
(Date:7/3/2015)... , July 3, 2015 ... 22 september 2015 på  http://www.openinnovationinscience.at till ... in Science" som hålls i ... färsk undersökning med internationella forskare och vetenskapsmän ... är hälsovetenskapens två största utmaningar bristen på ...
Breaking Biology Technology:ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3
Cached News: