HOME >> BIOLOGY >> NEWS
Location of potential familial lung cancer gene discovered

BETHESDA, Md., Mon., July 26, 2004 -- Researchers have discovered a possible inherited component for lung cancer, a disease normally associated with external causes, such as cigarette smoking. An interdisciplinary consortium consisting of 12 research institutions and universities, including the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both part of the National Institutes of Health (NIH), identified a major lung cancer susceptibility region on a segment of chromosome 6. The findings appear in a just-posted-online edition of American Journal of Human Genetics* and will appear in print in the September 2004 issue.

The Genetic Epidemiology of Lung Cancer Consortium (GELCC) ** examined 52 families who had at least three first-degree family members affected by lung, throat, or laryngeal cancer. Of these 52 families, 36 had affected members in at least two generations. Using 392 known genetic markers, which are DNA sequences that are known to be common sites of genetic variation, the researchers generated and then compared the alleles (the different variations each gene can take) of all affected and non-affected family members who were willing to participate in the study.

The researchers found strong evidence that a lung cancer susceptibility gene or genes is co-inherited with a genetic marker on chromosome 6. Markers on chromosomes 12, 14, and 20 also indicated possible linkage to lung cancer susceptibility, although the results were not as strong. Identifying the locus was a critical first step, but more work needs to be done.

"The genetic markers are like those mileage markers you see on the side of the highway," explained NCI's Jonathon Wiest, Ph.D. "They can be very useful for broad navigational purposes, but at the same time they don't give you precise information about all the interesting things that may lie along the highway."

The next goal for these researchers is to
'"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
26-Jul-2004


Page: 1 2 3

Related biology news :

1. Location of ulcerations in diabetic patients may be explained by blood flow
2. Lipoprotein lipase: Location, location, location.
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
5. Award winning researchers reveal potential new role for Glivec
6. Evidence builds for potential new cancer drug target
7. Scientists discover potential new way to control drug-resistant bacteria
8. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
9. OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
10. Managing occupational exposures to potential bioterrorist agents
11. Acamprosate: potential medication for treating alcoholism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/13/2016)... , January 13, 2016 ... published a new market report titled - Biometric Sensors Market ... Forecast, 2015 - 2023. According to the report, the global biometric ... is anticipated to reach US$1,625.8 mn by 2023, expanding ... In terms of volume, the biometric sensors market is ...
(Date:1/11/2016)... 11, 2016 Synaptics Incorporated (NASDAQ: SYNA ... announced that its ClearPad ® TouchView ™ ... two separate categories in the 8 th Annual ... Technology Breakthrough. The Synaptics ® TDDI solution enables ... chain, thinner devices, brighter displays and borderless designs. ...
(Date:1/8/2016)... and MANCHESTER, United Kingdom , ... a developer of innovative sensor-based diagnostic products, today announced the ... by new and existing investors.  Proceeds from the financing will ... Scanner , a hand-held device for detecting early-stage pressure ulcers. ... Ireland after receiving CE Mark approval. The ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... ... February 08, 2016 , ... Thomas J. Todorow has joined ... President for Corporate Services and the Chief Financial Officer at The Children’s Hospital ... Treasury, Managed Care Contracting, Supply Chain, and Investments. , Prior to joining CHOP ...
(Date:2/8/2016)... ... February 08, 2016 , ... Franz Inc. , an ... technology, today announced the availability of AllegroGraph 6, the leading Semantic Graph Database ... Certified Technology Program (CCPT). AllegroGraph is the first Semantic Graph Database to ...
(Date:2/8/2016)... 2016 --> ... "Company"), the ultra-rapid Point-Of-Care (POC) molecular diagnostics company, today announces ... trachomatis (CT) test to be launched on the Company,s io® ... the CT test is now cleared for sale within the ... The launch of the io® CT test signals a new ...
(Date:2/5/2016)... , Feb. 5, 2016  In the pharmaceutical ... for a host of launch activities including the identification ... this launch activity is especially high in the oncology ... Best Practices and the Role of Medical Affairs ... companies focused on oncology therapies find better ways to ...
Breaking Biology Technology:
Cached News: