HOME >> BIOLOGY >> NEWS
Location of ulcerations in diabetic patients may be explained by blood flow

April 9, 2003 (San Diego, CA) -- Sixty percent of hospital admissions of patients with diabetes are caused by complications of foot ulcers. More than 70 percent of these admissions require surgical intervention with 40 percent resulting in amputations. Of those with below knee amputations, 40 percent will require an amputation on the contralateral limb within three years.

It is estimated that at least half of the amputations are preventable through improved foot care programs. Unfortunately, significant portions of patients continue to develop plantar (sole of the foot) ulcers even with prescriptive footwear compliance. Consequently, efforts to understand the skin vasculature response to plantar pressures may provide insight into re-ulceration issues, since cutaneous perfusion is suspected to be influenced by arterial circulation but and the mechanical effects of repetitive pressure.

Background

Type II diabetes is related to poor glycemic control and if uncontrolled, leads to microvascular and neuropathic complications that can result in foot ulceration and amputation. Paramount to diabetes control is glycemic control due to the strong relationship between hyperglycemia, microvascular complications and neuropathic symptoms. Much work is being done to evaluate treatments for improved glycemic control. Research is ongoing, but the strong causal relationship between poor glycemic control, poor microcirculation and peripheral neuropathy continues to cause insensate feet, poor skin circulation, high plantar pressures, ulceration, and eventually amputation.

Fifty percent of diabetic patients have some degree of peripheral sensory neuropathy, with nerve damage increasing in incidence with the duration of disease. The most common type of peripheral neuropathy affecting diabetic patients is symmetric polyneuropathy involving distal sensory and motor fibers. This causes sensory loss and motor abnormalities in the distal parts o
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-967-2751
American Physiological Society
9-Apr-2003


Page: 1 2 3 4

Related biology news :

1. Location of potential familial lung cancer gene discovered
2. Lipoprotein lipase: Location, location, location.
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
5. Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
6. Why some diabetics are at greater risk for UTIs
7. Innovative self healing bandage to help diabetics
8. Scientist works to interrupt early changes resulting in diabetic vision loss
9. Could a specific protein contribute to erectile dysfunction for the diabetic and obese?
10. Pre-diabetic adults at increased risk of colon cancer
11. Islet cells from swine reverse insulin dependency in diabetic non-human primates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... The Blavatnik ... Winners and six Finalists of the 2017 Blavatnik Regional Awards for Young Scientists. ... Foundation and administered by the New York Academy of Sciences to honor the ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality ... Several trends in analytical testing are being attributed to new regulatory requirements for ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... ROTTERDAM, the Netherlands and LAGUNA HILLS, ... that The Institute of Cancer Research, London ... will use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify ... high-risk trial known as MUK nine . The University ... this trial, which is partly funded by Myeloma UK, and ...
Breaking Biology Technology:
Cached News: