HOME >> BIOLOGY >> NEWS
Location of ulcerations in diabetic patients may be explained by blood flow

April 9, 2003 (San Diego, CA) -- Sixty percent of hospital admissions of patients with diabetes are caused by complications of foot ulcers. More than 70 percent of these admissions require surgical intervention with 40 percent resulting in amputations. Of those with below knee amputations, 40 percent will require an amputation on the contralateral limb within three years.

It is estimated that at least half of the amputations are preventable through improved foot care programs. Unfortunately, significant portions of patients continue to develop plantar (sole of the foot) ulcers even with prescriptive footwear compliance. Consequently, efforts to understand the skin vasculature response to plantar pressures may provide insight into re-ulceration issues, since cutaneous perfusion is suspected to be influenced by arterial circulation but and the mechanical effects of repetitive pressure.

Background

Type II diabetes is related to poor glycemic control and if uncontrolled, leads to microvascular and neuropathic complications that can result in foot ulceration and amputation. Paramount to diabetes control is glycemic control due to the strong relationship between hyperglycemia, microvascular complications and neuropathic symptoms. Much work is being done to evaluate treatments for improved glycemic control. Research is ongoing, but the strong causal relationship between poor glycemic control, poor microcirculation and peripheral neuropathy continues to cause insensate feet, poor skin circulation, high plantar pressures, ulceration, and eventually amputation.

Fifty percent of diabetic patients have some degree of peripheral sensory neuropathy, with nerve damage increasing in incidence with the duration of disease. The most common type of peripheral neuropathy affecting diabetic patients is symmetric polyneuropathy involving distal sensory and motor fibers. This causes sensory loss and motor abnormalities in the distal parts o
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-967-2751
American Physiological Society
9-Apr-2003


Page: 1 2 3 4

Related biology news :

1. Location of potential familial lung cancer gene discovered
2. Lipoprotein lipase: Location, location, location.
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
5. Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
6. Why some diabetics are at greater risk for UTIs
7. Innovative self healing bandage to help diabetics
8. Scientist works to interrupt early changes resulting in diabetic vision loss
9. Could a specific protein contribute to erectile dysfunction for the diabetic and obese?
10. Pre-diabetic adults at increased risk of colon cancer
11. Islet cells from swine reverse insulin dependency in diabetic non-human primates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... Summary This report provides all the information ... partnering interests and activities since 2010. Download the ... Deals and Alliance since 2010 report provides an in-depth ... world,s leading life sciences companies. On demand ... of the most up to date deal and company ...
(Date:3/1/2017)... , March 1, 2017  Aware, Inc. (NASDAQ: AWRE), ... that Richard P. Moberg has resigned, effective ... and Chief Financial Officer and Treasurer of Aware citing ... serve as a member of the Board of Directors ... Aware,s co-Chief Executive Officer and co-President, General Counsel has ...
(Date:2/28/2017)...  EyeLock LLC, ein marktführendes Unternehmen im Bereich ... Lösung zur Iris-Erkennung auf der neuesten Mobilplattform ... dem Mobile World Congress 2017 (27. Februar ... 3, Stand 3E10, vorstellen. Der ... – eine Kombination aus Hardware, Software und ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... March 28, 2017 , ... METTLER ... modules. These weigh modules are designed according to European Hygienic Engineering & ... As fully integrated weighing solutions, SWB805 MultiMount weigh modules reduce contamination risk ...
(Date:3/27/2017)... ... March 27, 2017 , ... IsoPlexis Corporation (IsoPlexis), a ... disease and more through a single-cell precision engineering platform, today announced it has ... in the laboratory of Dr. James Heath at the California Institute of ...
(Date:3/27/2017)... 27, 2017  Perthera,s Chief Bioinformatics Officer and research ... Madhavan , Ph.D., will be speaking at the American ... Monday, March 27, 2017, she will be speaking on ... for Research and Care" (from 10:30 a.m. – 12:00 ... will be a participant in the "Making Precision Oncology ...
(Date:3/27/2017)... March 27, 2017 DarioHealth Corp. (NASDAQ: DRIO), ... and big data solutions, today announced that it is ... option for U.S. consumers who want to have their ... has signed strategic alliance agreements with partners across the ... benefits, and if approved, will supply and bill the ...
Breaking Biology Technology:
Cached News: