Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction

By specifically deleting the adhesion protein d-catenin, which is found exclusively in the brain, researchers at UCLA have found evidence that loss of d-catenin produces severe cognitive and synaptic dysfunction. Researchers have been particularly interested in d-catenin because clinical observations suggest it plays a critical role in brain function. Human chromosome-5 truncations that disrupt the function of the d-catenin gene correlate with the severity of mental retardation in Cri-du-Chat Syndrome; in addition, d-catenin is known to interact with Presenilin 1, the protein most often mutated in Familial Alzheimer's disease.

Despite these observations, until now there has been no evidence that specific deletions of d-catenin were sufficient to produce cognitive deficits. Also, although adhesion proteins have been shown to be critical for synaptic plasticity, a process by which brain circuits can be modified during learning, it has been unknown wether deletions of d-catenin would alter this process.

In the new work, researchers Inbal Israely and Xin Liu at UCLA show that mice with deletions of d-catenin display severe learning and memory deficits and thereby establish a causal link between deletions of d-catenin and cognitive dysfunction. This finding is particularly interesting because other adhesion proteins can be found in the brain, but only d-catenin is found specifically in neurons. The researchers also show that deletion of d-catenin produces severe deficits in short-lasting and long-lasting synaptic plasticity. In addition, they show that the synaptic composition of mutant animals is altered: the expression of several proteins involved in synaptic connectivity and plasticity is reduced in neurons from d-catenin mutant animals, possibly offering a clue to the mechanisms by which deletions of d-catenin cause synaptic and cognitive dysfunction. Ultimately, this work may facilitate the understanding of the mental retardation observed in Cri-du

Contact: Heidi Hardman
Cell Press

Page: 1 2

Related biology news :

1. Bim notes in the neuronal executioners song
2. Link between neuronal calcium channel, mutated gene that causes Huntingtons disease identified
3. Researchers find mechanism responsible for neuronal death in prion diseases
4. Lithographic technique creates neuronal networks in a dish
5. Pay attention to potassium channels! First steps in the molecular identification of SK channels and their role in neuronal signal encoding.
6. Improvement in some patients who underwent neuronal transplantation following stroke, according to study by University of Pittsburgh researchers
7. UV light, coatings reduce bacterial adhesion up to 50 percent
8. Nanoscale contact optimizes adhesion
9. Measurement clarifies role between protein structure and cell adhesion
10. Controlling cell adhesion: Researchers report first evidence of catch bonds
11. UC researchers have discovered novel cell adhesion mechanism that may lead to improved treatment for sickle cell disease

Post Your Comments:

(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
(Date:3/23/2017)... 23, 2017 The report "Gesture Recognition and Touchless Sensing ... Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is expected ... 29.63% between 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/9/2017)...  BioTech Holdings announced today identification and patenting ... stem cell therapy prevents limb loss in animal ... that treatment with ProCell resulted in more than ... to standard bone marrow stem cell administration.  Interestingly, ... of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses ... EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture Network ... at their fourth annual Conference where founders, investors, innovative practitioners and collaborators are ... pitch competition showcasing early stage digital health and med tech companies. , This ...
Breaking Biology Technology:
Cached News: