HOME >> BIOLOGY >> NEWS
Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction

By specifically deleting the adhesion protein d-catenin, which is found exclusively in the brain, researchers at UCLA have found evidence that loss of d-catenin produces severe cognitive and synaptic dysfunction. Researchers have been particularly interested in d-catenin because clinical observations suggest it plays a critical role in brain function. Human chromosome-5 truncations that disrupt the function of the d-catenin gene correlate with the severity of mental retardation in Cri-du-Chat Syndrome; in addition, d-catenin is known to interact with Presenilin 1, the protein most often mutated in Familial Alzheimer's disease.

Despite these observations, until now there has been no evidence that specific deletions of d-catenin were sufficient to produce cognitive deficits. Also, although adhesion proteins have been shown to be critical for synaptic plasticity, a process by which brain circuits can be modified during learning, it has been unknown wether deletions of d-catenin would alter this process.

In the new work, researchers Inbal Israely and Xin Liu at UCLA show that mice with deletions of d-catenin display severe learning and memory deficits and thereby establish a causal link between deletions of d-catenin and cognitive dysfunction. This finding is particularly interesting because other adhesion proteins can be found in the brain, but only d-catenin is found specifically in neurons. The researchers also show that deletion of d-catenin produces severe deficits in short-lasting and long-lasting synaptic plasticity. In addition, they show that the synaptic composition of mutant animals is altered: the expression of several proteins involved in synaptic connectivity and plasticity is reduced in neurons from d-catenin mutant animals, possibly offering a clue to the mechanisms by which deletions of d-catenin cause synaptic and cognitive dysfunction. Ultimately, this work may facilitate the understanding of the mental retardation observed in Cri-du
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
20-Sep-2004


Page: 1 2

Related biology news :

1. Bim notes in the neuronal executioners song
2. Link between neuronal calcium channel, mutated gene that causes Huntingtons disease identified
3. Researchers find mechanism responsible for neuronal death in prion diseases
4. Lithographic technique creates neuronal networks in a dish
5. Pay attention to potassium channels! First steps in the molecular identification of SK channels and their role in neuronal signal encoding.
6. Improvement in some patients who underwent neuronal transplantation following stroke, according to study by University of Pittsburgh researchers
7. UV light, coatings reduce bacterial adhesion up to 50 percent
8. Nanoscale contact optimizes adhesion
9. Measurement clarifies role between protein structure and cell adhesion
10. Controlling cell adhesion: Researchers report first evidence of catch bonds
11. UC researchers have discovered novel cell adhesion mechanism that may lead to improved treatment for sickle cell disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life ... for the life sciences and healthcare industries, announces a presentation by Subbu Viswanathan ... The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary ...
Breaking Biology Technology:
Cached News: