Lupus Research Institute awards $3 million in novel research grants to further new science in lupus

ersity of Pennsylvania, Philadelphia
APOPTOTIC NUCLEOSOMAL DNA AND ITS RELEVANCE IN SLE. Dr. Caricchio's research focuses on an important autoantigen in lupus, called nucleosome. Recent evidence suggests that nucleosomes are derived from a process called programmed cell death or apoptosis, and that such process may be the primary supplier of autoantigens for SLE, making apoptosis a potentially robust therapeutic target. This study aims to confirm the exact role that apoptotic nucleosomes play in the cause of SLE and pinpoint the source of this dangerous material. This work may provide a stronger rationale for targeting new therapies at apoptotic nucleosome.

  • Robert M. Clancy, PhD, New York University School of Medicine, Hospital for Joint Diseases, New York
    CIRCULATING ENDOTHELIAL CELLS, A BIOMARKER TO PREDICT SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH SLE. Dr. Clancy's research project will examine the relationship between circulating endothelial cells and the onset of atherosclerosis in lupus. These cells are activated by immune stimuli and are potential participants in the inflammatory process that contributes to tissue damage and atherosclerosis. Using a large patient base, Dr. Clancy's study will test this intriguing idea which could lead to a new therapy.

  • Mary K. Crow, MD, Hospital for Special Surgery, New York
    BIOMARKERS OF DISEASE FLARE IN SLE. A previous LRI grant recipient, Dr. Crow will examine several new candidate biomarkers that may reflect lupus flares. One set of potential biomarkers includes interleukin 8 (IL-8) and the interleukin 8 receptor. The second potential biomarker is an uncharacterized gene product with sequence similarity to regulators of RNA processing. Confirmation of either of these candidate genes will give us the ability to predict lupus flare and will advance testing of new therapies in patients.

  • Anne Davidson, MD, Albert Einste

  • Contact: Lydia Dorsky
    Lupus Research Institute

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