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Lupus Research Institute awards $3 million in novel research grants to further new science in lupus

in College of Medicine, New York
BIOMARKERS FOR RENAL REMISSION IN SLE. The goal of Dr. Davidson's study is to use real-time PCR and microarray technology to develop a clinical biomarker in lupus nephritis. The researchers will identify inflammatory molecules in the kidneys and urine that are associated with remission and relapse, and will use this information to study the urine of patients entering a clinical trial of a new therapeutic regimen for lupus nephritis.

  • Umesh S. Deshmukh, PhD, University of Virginia, Charlottesville
    ROLE OF KIDNEY ANTIGEN REACTIVE T CELLS IN THE PATHOGENESIS OF LUPUS GLOMERULONEPHRITIS. Dr. Deshmukh's research will investigate whether antibodies are always the basis of kidney disease in lupus, or whether there are other populations of T cells that can trigger the disease process, a very important question for the lupus community. He will also determine whether there is a relationship between the patient's gender and the progression of lupus to kidney disease.

  • Bevra H. Hahn, MD, UCLA Medical School, Los Angeles
    PRO-INFLAMMATORY HIGH DENSITY LIPOPROTEINS AS A BIOMARKER FOR RISK FOR ATHEROSCLEROSIS IN SLE. Dr. Hahn, collaborating with a cardiology group at UCLA, has found abnormal HDL cholesterol in some lupus patients, which promotes the oxidation of low density fats (OxLDL), leading to atherosclerosis. The LRI grant will allow Dr. Hahn to explore the abnormalities in HDL in lupus patients and determine their correlations with disease manifestations. Her research may lead to a new test for pro-inflammatory HDL to identify lupus patients at risk for atherosclerosis.

  • V. Michael Holers, MD, University of Colorado Health Sciences Center, University of Colorado School of Medicine, Denver
    COMPLEMENT RECEPTOR 2 AS A DNA RECEPTOR. Dr. Holers and colleagues are attempting to determine the importance of a newly discovered binding p
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  • Contact: Lydia Dorsky
    ldorsky@lupusny.org
    212-685-4118
    Lupus Research Institute
    16-Jun-2004


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