Lupus Research Institute awards $3 million in novel research grants to further new science in lupus

rotein that tightly interacts with DNA in the disease process. In this study, researchers will examine how this protein receptor binds with DNA and whether dysfunctional DNA binding is an important factor in triggering lupus.

  • Elahna Paul, MD, PhD, Massachusetts General Hospital, Harvard Medical School, Boston
    IMMUNO/RENAL INTERFACE IN MURINE LUPUS GLOMERULONEPHRITIS. By studying a mouse model of lupus glomerulonephritis, Dr. Paul will learn how kidney cells react to an autoimmune attack. She will examine early kidney lesions before clinical signs of the disease are present, with the goal of predicting the development of kidney disease in lupus patients.

  • David S. Pisetsky, MD, PhD, Duke University Medical Center, Durham
    ROLE O HMGB1 (HIGH MOBILITY GROUP PROTEIN) IN THE PATHOGENESIS OF SLE. Dr. Pisetsky's research will focus on a protein called HMGB1 that serves two functions in the body. Inside the cell, HMGB1 exists in the cell nucleus and binds DNA. Outside the cell, HMGB1 stimulates inflammation. Dr. Pisetsky will determine the process by which this protein is released into the blood when cells die and the mechanisms by which HMGB1 can stimulate an autoimmune response, and then he will determine whether HMGB1 may serve as a biomarker for lupus because of its association with inflammation and cell death. In addition, this work will uncover whether HMGB1 can be a target of therapy.

  • Luminita Pricop, MD, Hospital for Special Surgery, New York
    GENETIC AND ACQUIRED MODIFIERS OF APC FUNCTION IN SLE. Dr. Pricop's extremely novel research concept focuses on the role of inhibitory Fc receptors, a gene associated with lupus, in stimulating B and T cells. Her investigations will look at the mechanism that leads immune complexes to stimulate B and T cells, which could characterize new genetic markers for lupus.

  • Chander Raman, PhD, University of Alabama

  • Contact: Lydia Dorsky
    Lupus Research Institute

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