Lupus Research Institute awards $3 million in novel research grants to further new science in lupus

at Birmingham
CD5: A NOVEL TARGET FOR TREATMENT OF SLE. Dr. Raman's research is focused on targeting CD5, a novel target for treatment in lupus. Lupus is characterized by the presence of autoreactive T lymphocytes which activate autoreactive B lymphocytes and promote development and progression of the disease. The laboratory has recently made the novel discovery that the molecule CD5, expressed on all T-cells, is a key regulator of survival. The researchers propose that blocking the signal of CD5 will promote cell death of autoreactive T-cells, a potential target for therapy.

  • Robert A.S. Roubey, MD, University of North Carolina at Chapel Hill
    BIOMARKERS OF HYPERCOAGULABILITY IN SLE AND APS (ANTIPHOSPHOLIPID SYNDROME). Dr. Roubey's study will investigate the mechanisms of blood clotting in antiphospholipid syndrome (APS), a condition present in one-third of lupus patients that can lead to strokes, heart attacks and pregnancy loss. Researchers will use novel approaches to measure tissue factor activity to explain why some lupus patients tend to develop clots, and will assess whether newly developed blood tests can serve as a biomarker to identify the patients at risk for this condition.

  • Robert Winchester, MD, Columbia University College of Physicans and Surgeons, New York
    IDENTIFICATION OF BIOMARKERS IN CIRCULATING LEUKOCYTE SUBPOPULATIONS THAT IDENTIFY EVENTS IN THE MOLECULAR PATHOGENESIS OF SLE NEPHRITIS. The study seeks to identify biomarkers in circulating blood cells that predict the presence and clinical significance of either of two different patterns of lupus renal glomerular injury and inflammation recently identified in work by Dr. Karin Peterson and colleagues. One patient subset had a milder form of proliferative nephritis with interferon-induced genes suggesting the entrance of activated NK cells. A contrasting subset with more fibrosis had evidence of B cells, T cells

  • Contact: Lydia Dorsky
    Lupus Research Institute

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