MGH researchers first to identify genetic malfunction in type 1 diabetes

A research study from the Massachusetts General Hospital (MGH) has identified a gene malfunction that appears to be central to the development of type 1 diabetes. The study in a classic animal model of type 1 diabetes found that a gene required to help teach the immune system to recognize so-called "self" proteins is somehow inactivated, even though its sequence is not mutated. The scientists also found that the inactivation of this gene called Lmp2 has a profound impact on another key protein called nuclear factor kappa-B (NF-kB), a major controller of several immune system activities. Finding ways to correct or circumvent the malfunction identified in this study may lead to ways of preventing or stopping the autoimmune reaction at the heart of type 1 diabetes.

"This is a true genetic abnormality we can associate with type 1 diabetes," says Denise Faustman, MD, PhD, of the MGH Diabetes Unit, who led the study appearing in the December issue of Molecular and Cellular Biology. "While Lmp2 is located in a portion of the genome that had been linked to the disease, it hadn't been considered a candidate because its sequence is normal. But studying the gene's function has showed us a previously unsuspected problem: In the immune system cells we looked at, the Lmp2 protein virtually disappears by the time these mice reach a certain age, therefore most likely initiating their diabetes."

Type 1 diabetes (also called juvenile or insulin-dependent diabetes) is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells of the pancreas. Normally, immune system components called T cells learn not to attack the body's own tissues through the action of MHC Class I molecules, which sit on the surface of B cells and macrophages. There the molecules display tiny bits of "self" proteins to the T cells, the immune system's killers, essentially teaching them to ignore the body's own tissues. Another kind of MHC molecule, cal

Contact: Susan McGreevey
Massachusetts General Hospital

Page: 1 2 3

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:

(Date:8/26/2020)... SHANGHAI (PRWEB) , ... August 24, 2020 , ... ... approaches for the treatment of chronic inflammatory and fibrotic diseases, today announced that ... Vice President of Drug Discovery. , Dr. Canan previously served as Executive Director ...
(Date:8/21/2020)... ... August 18, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage ... Food and Drug Administration (FDA) has approved the company’s Investigational New Drug (IND) ... severe COVID-19. Approval of this IND allows Sentien to initiate a Phase 1/2 ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently announced ... for public health agencies of all sizes. With a focus on tracking symptoms ... find appropriate health care, Mosio helps public health departments automate communications and provide ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of ... and around the globe, requiring fast track capacity to provide patients with urgently ...
(Date:7/31/2020)... ... July 29, 2020 , ... The ... centers in 16 countries, has reached its 20th anniversary of worldwide use. Introduced ... use at top universities including University of Pennsylvania, University of Michigan, University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
Breaking Biology Technology:
Cached News: