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MGH researchers shed new light on how pain killers work

Woolf says that he is hopeful his teams findings will help lead to faster, more effective pain-killing drugs that have fewer side effects. He points to last years introduction of two Cox-2 selective drugs, which have been highly successful "blockbuster" pain relievers, as the possible beginning of a new era in pain relief. These drugs are designed to achieve the analgesic benefits of aspirin and aspirin-like products without the well-known side effects of gastric irritation and bleeding that are associated with NSAIDs that inhibit both Cox-1 and Cox-2.

"We believe that to have the maximum efficacy, the next generation of pain killers will need to focus on inhibiting central as well as peripheral production of PGE2," Woolf says. "Were tremendously excited about the potential to relieve suffering more effectively for millions of people around the world."


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Contact: Georgia W. Peirce
gpeirce@partners.org
617-724-6423
Massachusetts General Hospital
20-Mar-2001


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