HOME >> BIOLOGY >> NEWS
MGH study finds female mammals produce egg cells into adulthood

An underlying principle of female reproductive biology appears to have been overturned by a report from researchers at Massachusetts General Hospital (MGH). In an article in the March 11, 2004 issue of Nature, the investigators report that female mice retain the ability to make new egg cells well into adulthood. It has been believed that most female mammals are born with a finite supply of these cells, called oocytes, that are lost at a steady rate until the supply is exhausted, leading to menopause in women.

"If these findings hold up in humans, all theories about the aging of the female reproductive system will have to be revisited," says Jonathan Tilly, PhD, of the Vincent Center for Reproductive Biology at MGH, the paper's lead author. "We also may need to revisit the mechanisms underlying such environmental effects on fertility as smoking, chemotherapy and radiation. Eventually this could lead to totally new approaches to combating infertility in cancer patients and others." Tilly is an associate professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School.

For several years Tilly's group has been studying the mechanisms behind the death of oocytes and follicles, the tiny sacs in which the eggs grow. In both mice and humans, the vast majority of oocytes are destined to die through a process called programmed cell death or apoptosis, the body's natural way of eliminating unneeded or damaged cells. The team's earlier research confirmed that oocytes destroyed by chemotherapy drugs or radiation also die through apoptosis, opening the possibility of designing ways to stop ovarian damage in female cancer patients and perhaps to postpone normal ovarian failure. However, to provide an essential context to their efforts to inhibit oocyte apoptosis, the researchers decided to measure the numbers of healthy and dying follicles in mouse ovaries through the animals' lifespan.

What they found was remarkable. Measuremen
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
10-Mar-2004


Page: 1 2 3 4

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MGH study finds female mammals produce egg cells into adulthood

(Date:11/4/2014)... death at the right time might actually help boost ... could help in understanding animal populations, pest control and ... in the journal Trends in Ecology and Evolution ... that the kind of positive population effect an overall ... depends on the size and developmental stage of the ...
(Date:11/4/2014)...   3D scanner developer targets ... Fuel3D , a developer of 3D scanning solutions, today announced ... (£4 million). This funding builds on the company,s initial $2.6 ... the way for the commercial launch of the company,s consumer ... led by Chimera Partners and will be used to ramp-up ...
(Date:11/3/2014)... A University of Colorado Cancer Center study ... Academy of Sciences describes the activity of a ... Interleukin 37 or IL-37. It has been known to ... in the adaptive immune system: IL-37 inhibits the ability ... antigens. , "Knowing this mechanism that underlies IL-37,s effect ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
(Date:11/18/2014)... Sarasota, FL (PRWEB) November 17, 2014 ... novel point-of-care diagnostic tests – today announces its ... Control and Prevention’s (CDC) Get Smart About Antibiotics ... Antibiotics Week is a national campaign designed to ... local health departments, and non-profit and for-profit partners ...
(Date:11/18/2014)... (PRWEB) November 18, 2014 American ... Australia) recently formed a partnership with researchers at ... University of Technology, and the USDA’s Forest Products ... reinforced with nanocellulose. Nanocellulose is a rapidly emerging ... of the project is to replace heavy steel ...
(Date:11/18/2014)... MENLO PARK, Calif. , Nov. 18, 2014 ... leading biotechnology company in the emerging field of ... clinical program, AST-OPC1 (oligodendrocyte progenitor cells) for complete ... as one of ten "Top Advanced Therapies Projects ... "We are delighted to receive this significant industry ...
(Date:11/16/2014)... 17, 2014 The “Fluid Management ... fluid visualization systems market with an analysis and ... & irrigation, dialyzes, fluid warming and waste management. ... the fluid visualization systems by applications and regions ... market was valued at $19,285.5 million in 2013 ...
Breaking Biology Technology:RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 2Asterias Biotherapeutics Named as a "Top Advanced Therapies Projects to Watch" and Will Present at the Therapeutic Area Partnerships Conference 3Fluid Visualization Systems Market poised to reach $25,908.4 Million by 2018 - New Research Report by MarketsandMarkets 2Fluid Visualization Systems Market poised to reach $25,908.4 Million by 2018 - New Research Report by MarketsandMarkets 3Fluid Visualization Systems Market poised to reach $25,908.4 Million by 2018 - New Research Report by MarketsandMarkets 4
Cached News: