HOME >> BIOLOGY >> NEWS
MGH study finds female mammals produce egg cells into adulthood

An underlying principle of female reproductive biology appears to have been overturned by a report from researchers at Massachusetts General Hospital (MGH). In an article in the March 11, 2004 issue of Nature, the investigators report that female mice retain the ability to make new egg cells well into adulthood. It has been believed that most female mammals are born with a finite supply of these cells, called oocytes, that are lost at a steady rate until the supply is exhausted, leading to menopause in women.

"If these findings hold up in humans, all theories about the aging of the female reproductive system will have to be revisited," says Jonathan Tilly, PhD, of the Vincent Center for Reproductive Biology at MGH, the paper's lead author. "We also may need to revisit the mechanisms underlying such environmental effects on fertility as smoking, chemotherapy and radiation. Eventually this could lead to totally new approaches to combating infertility in cancer patients and others." Tilly is an associate professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School.

For several years Tilly's group has been studying the mechanisms behind the death of oocytes and follicles, the tiny sacs in which the eggs grow. In both mice and humans, the vast majority of oocytes are destined to die through a process called programmed cell death or apoptosis, the body's natural way of eliminating unneeded or damaged cells. The team's earlier research confirmed that oocytes destroyed by chemotherapy drugs or radiation also die through apoptosis, opening the possibility of designing ways to stop ovarian damage in female cancer patients and perhaps to postpone normal ovarian failure. However, to provide an essential context to their efforts to inhibit oocyte apoptosis, the researchers decided to measure the numbers of healthy and dying follicles in mouse ovaries through the animals' lifespan.

What they found was remarkable. Measuremen
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
10-Mar-2004


Page: 1 2 3 4

Related biology news :

1. Student science contest participation influences study, career choices, alumni say
2. New study shows hope for treating inhalant abuse
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Indiana University, EPA to study airborne PCBs
9. K-State, other universities to study how climate affects plant evolution
10. USC study links historical increases in life span to lower childhood exposure to infection
11. Washington University in St. Louis leads group studying aging process

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/10/2019)... British Columbia (PRWEB) , ... October 09, 2019 ... ... Sigma Anti-Bonding Calcium Symposium (ISACS) 2019 at Executive Plaza Hotel in Vancouver, Canada ... and share the knowledge of the various measures to develop healthy bone and ...
(Date:10/8/2019)... ... October 07, 2019 , ... Imaging data sets are generated ... optical projection tomography, optical coherence tomography, echocardiogram, light sheet microscopy, MRI and X-ray ... inhouse, a lot of research groups struggle with transforming these large and sometimes ...
(Date:10/3/2019)... ... October 01, 2019 , ... The CHEM+POUR Bag ... medias and to be a more environmentally sustainable evolution to plastic or glass ... experience and feedback from the original version we launched in September 2015,” said ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... Personalized ... training and site qualification for clinical trial sites and physician investigators. The ... potential clinical trial participants. , Clinical trial sites are currently located in San ...
(Date:9/24/2019)... (PRWEB) , ... September 24, 2019 , ... In the ... for research led by faculty at South Dakota School of Mines & Technology ... tiny microbes that attach to surfaces to form a slimy and yet strong layer ...
(Date:9/17/2019)... ... September 17, 2019 , ... Catalent, ... Project and Clinical Supplies Management, Asia Pacific (APAC) will present at the upcoming ... on Sept. 25-26, 2019. , On Thursday, Sept. 26, at 10:10 a.m., Ms. ...
(Date:9/17/2019)... ... September 17, 2019 , ... Geneticure, Inc., a Rochester ... today that the U.S. Patent and Trademark Office (USPTO) and European Patent Office ... class recommendations for hypertension treatment. , The patent applies to Geneticure’s first ...
Breaking Biology Technology:
Cached News: