MGH study finds female mammals produce egg cells into adulthood

ound in most cells. Finding a protein that is only produced at the onset of meiosis in ovarian cells of young and mature mice indicated that this aspect of oocyte development continues after birth.

  • Busulfan is a chemotherapy drug known to target proliferating germ cells in males but have no effect on mature sperm cells. Three weeks after being injected with busulfan, female mice were found to have only 5 percent the supply of primordial (immature) follicles than control mice had. The investigators went on to show this difference was not due to increased death of primordial follicles, implying that the busulfan-related drop in the number of primordial follicles resulted from an absence of follicular renewal.

  • The researchers grafted ovarian tissue from normal adult mice onto the ovaries of adult transgenic mice that express a green marker protein in all of their cells. Several weeks later the grafted ovaries in the transgenic mice were found to contain hybrid follicles consisting of normal follicular cells surrounding green oocytes. These results demonstrated that transgenic (green) germ cells had migrated from the host ovary into the grafted ovarian tissue and produced green oocytes, which formed new follicles from the surrounding normal cells.

    Tilly says that the concept of a fixed pool of oocytes, first asserted almost a century ago, has been so widely accepted that he is not aware of any studies over the past 50 years that have questioned its accuracy. "The ovaries visibly lose healthy follicles throughout life, while the testes continue to look the same. It was assumed that the decline in total follicles represented the gradual disappearance of a limited supply of oocytes. No one ever attempted to measure the actual rate of oocyte or follicle death before because the dogma was so persuasive," he explains.

    Among many potential implications of the study is a different mechanism underlying ovarian aging. It is known t

  • Contact: Sue McGreevey
    Massachusetts General Hospital

    Page: 1 2 3 4

    Related biology news :

    1. Student science contest participation influences study, career choices, alumni say
    2. New study shows hope for treating inhalant abuse
    3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
    4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
    5. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
    6. Phase II trials of second-generation antisense cancer drug planned following successful early study
    7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
    8. Indiana University, EPA to study airborne PCBs
    9. K-State, other universities to study how climate affects plant evolution
    10. USC study links historical increases in life span to lower childhood exposure to infection
    11. Washington University in St. Louis leads group studying aging process

    Post Your Comments:

    (Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
    (Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
    (Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
    Breaking Biology News(10 mins):
    (Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
    (Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
    (Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
    (Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
    Breaking Biology Technology:
    Cached News: