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MRI technique lets researchers directly compare monkey and human brains

COLUMBUS, Ohio Researchers have developed a new way to use a decade-old imaging method to directly compare the brains of monkeys with those of humans. Their report appeared in the journal Science.

The method uses functional Magnetic Resonance Imaging (fMRI) a technique that measures blood volume and flow and blood-oxygen levels in the brain. It also provides an indirect measure of neuronal activity in different regions of the brain.

Neurons need oxygen and glucose to work. Blood carries both substances, and both can cross the blood-brain barrier. When a particular region of the brain is activated, the blood flow to that area temporarily increases in order to supply the neurons with fresh oxygen and glucose.

What were doing is an indirect measurement of the human brains electrical activity, said Wim Vanduffel, the reports lead author and an instructor at the Athinoula A. Martinos Center for Biomedical Imaging in Charlestown, Mass.

Its the best way at present for investigating patterns of neural activity in humans, he said.

The researchers used the same fMRI technique on humans and on monkeys to compare activity in an area of the brain called the visual cortex, the region that proces
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Contact: James Todd
Todd.44@osu.edu
614-292-8661
Ohio State University
21-Oct-2002


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