ge football field," says IMB co-director Michael Grunze, who holds joint appointments with the University of Maine, The Jackson Laboratory and the University of Heidelberg in Germany. "Now, imagine being able to see the football itself, in 3D. The 4Pi represents a comparable increase in resolution, only on a nanoscale."
"In addition to applications involving imaging of genes and nuclear structure," says Kenneth A. Ault, MD, director of MMCRI, "our researchers are particularly interested in using this microscope to image large, multi-molecular structures migrating within and across the cell membrane. For example, a recent discovery at MMCRI indicates that controlling the migration of fibroblast growth factor can prevent reocclusion of coronary arteries after angioplasty. We are confident that this fruitful collaboration with the physicists in the IMB will reveal many as yet unsuspected discoveries of value to the medical community."
The National Science Foundation grant for the acquisition of the 4Pi also includes funding for a specialized microscopist, most likely a physicist, to analyze samples on the 4Pi. Grunze anticipates that researchers will be able to send or bring biological samples to the IMB for analysis. "I see biology moving towards specialized high-tech centers like the IMB, bringing in investigators from all over the world," he said.
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Contact: Joyce Peterson
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