HOME >> BIOLOGY >> NEWS
Major Risk Factor For Cervical Cancer Found

Scientists have found that women who carry a particular variation of the tumour suppressor gene p53 are seven times more likely to develop cervical cancer that those who do not. The researchers' findings are published today (21 May 1998) in the science journal Nature*.

The work was carried out by scientists from the Imperial Cancer Research Fund (ICRF) Skin Tumour Laboratory and Department of Medical Microbiology at St Bartholomew's and Royal London Hospital School of Medicine and Dentistry, London, the International Centre for Genetic Engineering and Biotechnology, Italy, and the Institute for Parasitology and McGill Cancer Centre, Quebec, Canada.

Doctors already know that infection by certain types of the Human Papillomavirus (HPV) is almost essential for cervical cancer to develop. Major advances have been made in understanding how these viruses cause cancer. However, much less in known about how an individuals' genetic makeup may contribute to cervical cancer development.

P53 is a key control point in the body's defence against tumour formation. It protects the genetic information in the cells from things which can damage them such as ultra violet radiation or certain chemicals. If p53 goes wrong then a cell has a greater chance of becoming cancerous.

Dr Alan Storey, leader of the ICRF research team, explained: "P53 is often defective in many forms of cancer but in cancers caused by the Human Papillomavirus (HPV) it is usually normal. Instead, HPV produces a protein, called E6, which stops p53 from working correctly."

People can carry one of two variations of the p53 gene, p53Arg or p53Pro. The researchers found that p53Arg is more easily inactivated by the HPV protein. This suggested that people who carry only p53Arg might be less well protected against the effects of HPV.

Said Dr Storey: "We found that cervical cancers resulting from HPV infection were significantly more likely to occur in women who had only p53Arg.
'"/>

Contact: Christine Suggars
suggars@icrf.icnet.uk
+44-171-269-3614
Imperial Cancer Research Fund
21-May-1998


Page: 1 2 3

Related biology news :

1. Major scientific discovery in cancer research to be honored
2. Major U.S. environmental policy bears scrutiny in midlife
3. Major boost for European zebrafish research
4. Major mutations, not many small changes, might lead way to new species
5. Major new finding on genetics of Parkinsons disease zeroes in on activity of alpha synuclein
6. Major stress during pregnancy linked to autism
7. Major fossil find reveals Asian origins of salamanders
8. Major unique new study shows infrequent inspections lead to greater stream pollution
9. Major new initiative to resolve structure of protein families
10. Major air pollution study launched
11. Major grant to aid McGill University professors efforts to improve school science teaching

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/14/2020)... ... May 13, 2020 , ... DuPont ... latest enzyme for the lactose-free dairy market. This unique product allows for process ... dairy products at competitive costs across North America. , Among the numerous benefits ...
(Date:5/1/2020)... LAUDERDALE, Fla. (PRWEB) , ... April 30, 2020 ... ... accredited telemedicine company backed by Siemens Healthineers and several healthcare VC firms announces ... COVID-19, the goal of CareDoctors.com is to enhance patient care experience by offering ...
(Date:4/30/2020)... , ... April 28, 2020 , ... ... are Lachman Consultants latest effort in providing timely and critical information to life ... by social distancing and health safety concerns. , “Providing the most up-to-date actionable ...
Breaking Biology News(10 mins):
(Date:5/21/2020)... Prairie, MN (PRWEB) , ... May 19, 2020 , ... ... to help patients get dental implants and bone grafting through PIEZOSURGERY® technology. ... tissues. This is often used to prepare a patient for dental implants, especially when ...
(Date:5/15/2020)... ... ... This new service offers clients a way to speak with Subject Matter Experts ... arises. Lachman’s OnCall SMEs have extensive knowledge of a wide range of scientific, technical, ... are available normal business hours Monday through Friday from 9:00 am – 5:00 pm ...
(Date:5/14/2020)... ... , ... Early stages of drug discovery often depend on ... the drug’s mechanism of action (MOA). Gene expression profiling technologies like RNA sequencing ... molecular pathways. This information can complement phenotypic readouts and can be used to ...
(Date:5/1/2020)... ... 2020 , ... The winners of Fast Company’s 2020 World ... that are actively engaged and deeply committed to changing the world. Amongst the ... top prize in the Experimental category. , The RASTRUM™ 3D Bioprinter from Inventia ...
Breaking Biology Technology:
Cached News: