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Major boost for European zebrafish research

The analysis of the activity (expression) of tens of thousands of zebrafish genes on gene chips (microarrays) that will help to understand how they regulate each other's activity during normal development, and how this regulation is disturbed in mutants.

The generation of thousands of fish expressing Green Fluorescent Protein (GFP) controlled by the enhancer sequences of specific genes. Under UV light, tissues of these fish will light up indicating wherever the respective gene is active.

A facility to knock-out genes that will provide European researchers with zebrafish mutants for specific genes on demand. This will let them study genes of particular interest for which no mutant is found in the mutagenesis projects. The knock-out fish will be suitable as models for human diseases and the development of therapies.

A European zebrafish database that will integrate all project data in a three-dimensional anatomical atlas of zebrafish development, linked with the relevant gene activities. This database will be accessible through the project web site (www.zf-models.org) and will be open to scientists and the interested public world-wide.


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Contact: Dr. Ralf Dahm - Project Manager
ralf.dahm@tuebingen.mpg.de
49-7071-601-444
Max-Planck-Gesellschaft
9-Feb-2004


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