Making A Hand Or A Foot? Tbx-4 And Tbx-5 Are Involved In Determination Of Fore- And Hindlimb Identity

The development of limb structures is regulated by molecular signalling cascades, some of which have been well defined to date. Similar signalling pathways are involved in outgrowth and patterning in both the fore- and hindlimbs. However, in the chick fore- and hindlimbs are also characterised by marked morphological differences. For example, while the forelimb (wing) develops three digits and is completely covered by feathers, the hindlimb (leg) develops 4 digits and is covered by scales and tuberculae.

Members of the T-box family have been identified in a variety of invertebrates and vertebrates, including humans. These genes encode transcription factors which are involved in regulation of gene transcription.

Tbx4 and Tbx5 genes are specifically expressed in the leg bud and wing bud respectively. Previous studies correlated these genes with specification of limb type identity. Toshihiko Ogura, Jun Takeuchi and coworkers (Nara Institute of Science and Technologie, Nara, Japan) in collaboration with Astrid Vogel-Höpker (Max Planck Institute for Brain Research, Frankfurt/Main, Germany, a recipient of a Japan Promotion of Science Fellowship ) have now shown that misexpression of Tbx4, a hindlimb specific gene, in the presumptive forelimb region of the chick embryo, induced the development of a leg-like structure at the position, where normally a forelimb would develop. The corresponding result, induction of forelimb-like structures in the hindlimb region was observed when the forelimb-specific gene Tbx5, was misexpressed in that region. The phenotypes of these misexpression studies were apparant both morphologically and on the basis of limb-specific expression of molecular markers (e.g. Hox genes). For example, misexpression of Tbx4 in the presumptive forelimb region induced the expression of hindlimb specific genes. In some cases Takeuchi et al could also induce the development of 4 digits and scale formation which are features characteristic f

Contact: Astrid Vogel-Höpker

Page: 1 2 3

Related biology news :

1. Making a friendlier mosquito
2. Making sense of the brains mind-boggling complexity
3. Making protein nanostructures
4. Making the most of stem cells
5. Making of mouse marks move toward mitochondrial medicine
6. Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
7. Making sense of bacterial biodiversity
8. Making sense of the genome
9. Making a safer anthrax vaccine using spinach
10. A new twist on an age-old problem: Making knee replacements last
11. Making sense of Marfan syndrome

Post Your Comments:

(Date:9/25/2019)... ... September 25, 2019 , ... The esteemed dental ... 20,000 dental implants for a variety of procedures, including single tooth replacement, new ... implants. Dental implants offer patients permanent tooth replacement solutions that look ...
(Date:9/24/2019)... ORLANDO, Fla. (PRWEB) , ... September 24, 2019 ... ... development of its technology driven portfolio of 3D porous titanium spinal implants with ... increases it’s Ti3D implant offerings while more than tripling the number of cervical ...
(Date:9/17/2019)... ... September 17, 2019 , ... Last week, Blackrock ... engineers from the Medical University of Warsaw, met at the Presidential Palace of ... creating a neuroprosthetic system as part of an initiative called "Startups in the ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... ... September 17, 2019 , ... Jennifer Hermansky and ... , have been named to Law360’s 2019 Rising Stars. Hermansky and Xie, named an ... attorneys from 1,300 submissions, spanning 39 practice areas. The list highlights attorneys “whose legal ...
(Date:9/17/2019)... (PRWEB) , ... September 16, 2019 , ... ... Nationwide via CNBC on Saturday, September 21st @11:00am ET. Check local listings for ... Pte. Ltd. (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to ...
(Date:9/11/2019)... ... September 09, 2019 , ... ... and government agencies, announced that its president and CEO Maryann Gallivan has been ... leaders. , The Forbes Council accepted Gallivan based on the role she and ...
(Date:9/11/2019)... ... September 10, 2019 , ... An upcoming episode of ... developments in genome sequencing analysis. Check your local listings for more information. , ... Research & Consulting and will explore its revolutionary pathogenic DNA analysis technology, which ...
Breaking Biology Technology:
Cached News: