HOME >> BIOLOGY >> NEWS
Making sense of the genome

Almost every week we hear of a new genome sequence being completed, yet turning sequence information into knowledge about what individual genes do is very difficult. An article published in Journal of Biology this week will simplify this task, as it describes a new online tool that dramatically improves predictions of how individual genes are regulated.

Dr. Wyeth Wasserman and his team have created this powerful new two-step method for identifying which regulators of gene expression, called transcription factors, are in control of individual genes. The new method is far more selective than its predecessors, reducing the number of biologically irrelevant transcription factors identified in a search by 85%. The researchers have now made the tool available through an easy to use website called ConSite.

This web-based tool will be particularly helpful in analysing genes whose coding sequences do not give any clues as to their function. Around 30% of the predicted human genes contain no recognisable domains. Through knowing which transcription factors control the expression of a particular gene, scientists can get an idea as to what processes the gene is involved in. This is because transcription factors are themselves tightly controlled to ensure that a gene is only expressed when and where it is needed, and a great deal is already known about which events activate which transcription factors.

"Knowledge of the identity of a mediating transcription factor can give important insights into the function of a gene," according to the authors of the article.

Transcription factors act by binding to specific sequences in a regulatory region that is located in the DNA upstream of the coding region. But they can tolerate a large amount of variation in these sequences. This means that searching an upstream regulatory region for transcription factor binding sites identifies a large number of such sites, most of which are biologically i
'"/>

Contact: Gemma Bradley
press@biomedcentral.com
44-207-323-0323
BioMed Central
22-May-2003


Page: 1 2 3

Related biology news :

1. Making a friendlier mosquito
2. Making sense of the brains mind-boggling complexity
3. Making protein nanostructures
4. Making the most of stem cells
5. Making of mouse marks move toward mitochondrial medicine
6. Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
7. Making sense of bacterial biodiversity
8. Making a safer anthrax vaccine using spinach
9. A new twist on an age-old problem: Making knee replacements last
10. Making sense of Marfan syndrome
11. Making the most of lymphopenia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2017)... 2017 Future of security: Biometric Face Matching software  ... ... DERMALOGs Face Matching enables to match face pictures against each other or ... individuals. (PRNewsFoto/Dermalog Identification Systems) ... "Face Matching" is the fastest software for biometric Face Matching on the market. ...
(Date:3/7/2017)... BRIGHTON, England , March 7, 2017 Brandwatch ... been chosen by The Prince,s Trust to uncover insights ... insights across The Trust. The UK,s leading youth charity ... track social campaign results and get a better understanding of the ... ...
(Date:3/2/2017)... YORK , March 2, 2017 Summary ... better understand Perrigo and its partnering interests and activities since ... ... Partnering Deals and Alliance since 2010 report provides an in-depth ... leading life sciences companies. On demand company reports ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... SPRINGS, CO , March 29, 2017 /PRNewswire/ - Last year,s ... support kratom are not the only efforts active to generate awareness ... substitute opiate based pharmaceutical drugs in the healthcare market place. ... Earlier this month ... based developer and distributor of pharmaceutical and nutritional products, announced its ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... Nerium International Mexico has been approved as an active member of the ... and protection among distributers and consumers in relationship marketing. This professional organization fosters ...
(Date:3/29/2017)... SAN DIEGO , March 29, 2017 /PRNewswire/ ... developing novel oncology and drug-delivery therapies, today announced ... U.S. Food and Drug Administration voted 11 to ... (under the skin) injection was favorable for patients ... large B-cell lymphoma and chronic lymphocytic leukemia. The ...
(Date:3/29/2017)... ... 2017 , ... Cancer diagnostics and pathology workflow solution provider ... Association of Community Cancer Centers (ACCC) 43rd Annual Meeting, CANCERSCAPE at ... stakeholders from leading national organizations to share insights on how value-based care, drug ...
Breaking Biology Technology:
Cached News: