HOME >> BIOLOGY >> NEWS
Making sense of the genome

Almost every week we hear of a new genome sequence being completed, yet turning sequence information into knowledge about what individual genes do is very difficult. An article published in Journal of Biology this week will simplify this task, as it describes a new online tool that dramatically improves predictions of how individual genes are regulated.

Dr. Wyeth Wasserman and his team have created this powerful new two-step method for identifying which regulators of gene expression, called transcription factors, are in control of individual genes. The new method is far more selective than its predecessors, reducing the number of biologically irrelevant transcription factors identified in a search by 85%. The researchers have now made the tool available through an easy to use website called ConSite.

This web-based tool will be particularly helpful in analysing genes whose coding sequences do not give any clues as to their function. Around 30% of the predicted human genes contain no recognisable domains. Through knowing which transcription factors control the expression of a particular gene, scientists can get an idea as to what processes the gene is involved in. This is because transcription factors are themselves tightly controlled to ensure that a gene is only expressed when and where it is needed, and a great deal is already known about which events activate which transcription factors.

"Knowledge of the identity of a mediating transcription factor can give important insights into the function of a gene," according to the authors of the article.

Transcription factors act by binding to specific sequences in a regulatory region that is located in the DNA upstream of the coding region. But they can tolerate a large amount of variation in these sequences. This means that searching an upstream regulatory region for transcription factor binding sites identifies a large number of such sites, most of which are biologically i
'"/>

Contact: Gemma Bradley
press@biomedcentral.com
44-207-323-0323
BioMed Central
22-May-2003


Page: 1 2 3

Related biology news :

1. Making a friendlier mosquito
2. Making sense of the brains mind-boggling complexity
3. Making protein nanostructures
4. Making the most of stem cells
5. Making of mouse marks move toward mitochondrial medicine
6. Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
7. Making sense of bacterial biodiversity
8. Making a safer anthrax vaccine using spinach
9. A new twist on an age-old problem: Making knee replacements last
10. Making sense of Marfan syndrome
11. Making the most of lymphopenia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2019)... ... 31, 2019 , ... Advancements with Ted Danson to focus ... information. , Factor Bioscience Inc. (Factor) is pioneering nucleic-acid and cell-based technologies to ... segment of Advancements will explore how Factor Bioscience is building the future of ...
(Date:7/24/2019)... ... July 24, 2019 , ... NDA ... a quality assurance expert with more than 20 years of experience working in ... has joined the firm as an Expert Consultant. , Dr. Hartzfeld has experience ...
(Date:7/21/2019)... ... July 20, 2019 , ... ... ) announced today the release of the biggest software update in its ... platform will provide a significant increase in productivity for its users. ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... ... July 16, 2019 , ... Quidel is the market ... Information. Abbott, Roche and Siemens Healthineers and Response Biomedical also are among the ... Market for Point-of-Care (POC) Diagnostics . , Quidel is a market leader in ...
(Date:7/9/2019)... ... 2019 , ... Balluff has been named a 2019 “Best ... Innovative Product of the Year which highlights cutting-edge advancements and achievements that are ... & Conference 2019, held this week in San Jose, California. , Utilizing ...
(Date:6/18/2019)... YORK and SOMERSET, N.J. (PRWEB) , ... June ... ... Catalent Biologics, today announced that they have entered into an agreement for production ... product candidates, IC-100 for the treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) ...
(Date:6/11/2019)... ... 2019 , ... Thought Technology Ltd is pleased to announce ... Tech Ltd as its authorised distributor for the UK and Ireland. , ... and clinical assessment protocols to treat stress related disorders as well as provide ...
Breaking Biology Technology:
Cached News: