HOME >> BIOLOGY >> NEWS
Malignant breast cancer cells to revert to normal with manipulation

Speaking at Experimental Biology 2004, Dr. Mina Bissell describes research showing how manipulation of the extracellular matrix (a network of fibrous and globular proteins that surrounds breast cells) of non-malignant breast cells can lead to genomic instability via oxidative damage. She describes how manipulation of the microenvironment can allow malignant breast cancer cells to revert to normal cells again. She also describes how the tissue culture of the extracellular matrix affects the cancerous cells' resistance to chemotherapy, independently of the characteristics of the malignancy itself.

Her presentation is part of the scientific program of the American Association of Anatomists, one of the six sponsoring societies of this year's Experimental Biology meeting.

Dr. Bissell, a Distinguished Scientist at the Lawrence Berkeley Laboratory, is best known as the researcher who uncovered the critical role of extracellular matrix (ECM) in normal breast function and how its aberration may contribute to breast cancer development. While the role of ECM during embryonic development had been recognized for decades, its important role in tissue-specific function was not appreciated before the work in a handful of laboratories including Dr. Bissell's laboratory. In fact, ECM was regarded as scaffolding for tissues and not much more.

Dr. Bissell postulated in 1981, and later showed experimentally, that the ECM was part of a "dynamic reciprocity" in the social interaction between cells and the nucleus much like hormones and growth factors, with the ECM at times telling the nucleus of the cells what to do and thus directing gene expression in conjunction with these other factors. She had chosen the breast to study the critical role of the ECM in normal breast tissue, a model she had selected because it continues to change throughout life of women in puberty, pregnancy, lactation, and once breast feeding is done (involution). In some of their earliest
'"/>

Contact: Sarah Goodwin
eb4press@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
18-Apr-2004


Page: 1 2 3

Related biology news :

1. Malignant cancer cells generate mice through cloning
2. Certain genes boost fish oils protection against breast cancer
3. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
4. Progress in breast cancer progression
5. The telomere crisis: A crucial stage in breast cancer
6. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
7. More aggressive breast cancer tumors found in African American women
8. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
9. Study links high carbohydrate diet to increased breast cancer risk
10. UCI study reveals gene linked to breast cancer can suppress tumors
11. Animal research suggests plant estrogens in soy do not increase breast cancer risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring announced that ... has secured the final acceptance by all three ... Access Systems (MAS) installed. Furthermore, Securus will have ... installed by October, 2016. MAS distinguishes between legitimate ...
(Date:6/7/2016)... TORONTO , June 7, 2016  Syngrafii ... begun a business relationship that includes integrating Syngrafii,s ... pilot branch project. This collaboration will result in ... for the credit union, while maintaining existing document ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and ... clinical trial team. , Using the CONSULT module, patients and physicians can schedule a ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
Breaking Biology Technology:
Cached News: