HOME >> BIOLOGY >> NEWS
Malignant cancer cells generate mice through cloning

Nature can reset the clock in certain types of cancer and reverse many of the elements responsible for causing malignancy, reports a research team led by Whitehead Institute Member Rudolf Jaenisch, in collaboration with Lynda Chin from Dana Farber Cancer Institute. The team demonstrated this by successfully cloning mice from an advanced melanoma cell.

"This settles a principal biological question," says Jaenisch, who also is a professor of biology at MIT. "The epigenetic elements of cancer are reversible; the genetic elements, as expected, are not."

Researchers have known for decades that cancer begins when certain key genes in an otherwise healthy cell mutate, and tumor growth depends on continuing, multiple mutations. But only recently have scientists begun to understand the "epigenetic" components of cancer-that is, how other molecules in a cell affect genes without actually altering the sequence of DNA. Many of these epigenetic components, such as methylation, can determine if a gene is silent or active.

Konrad Hochedlinger and Robert Blelloch, postdoctoral researchers in the Jaenisch lab, studied whether any of these epigenetic influences can be reversed. First, they removed the nucleus from a melanoma cell and injected it into a de-nucleated egg cell (a process known as nuclear transfer). After the egg cell developed into a blastocyst, Hochedlinger and Blelloch harvested embryonic stem cells which they then incorporated into a group of healthy mouse blastocysts. Many of these blastocysts developed into normal adult mice. The work was reported in the August issue of the journal Genes and Development.

"It's important to note," says Blelloch, "that the stem cells from the cloned melanoma were incorporated into most, if not all, tissues of adult mice, showing that they can develop into normal, healthy cells," such as those for skin pigmentation, immunity, and connective tissue. But in spite of this, when certain cancer-related g
'"/>

Contact: David Cameron
newsroom@wi.mit.edu
617-258-5183
Whitehead Institute for Biomedical Research
2-Aug-2004


Page: 1 2

Related biology news :

1. Malignant breast cancer cells to revert to normal with manipulation
2. Leader in cancer treatment and prevention research honored
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Chemical derived from vitamin-E shows early promise as cancer drug
5. New molecular link key to cellular proteins involved in cancer progression, other diseases
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Trial shows which brain cancer patients benefit from temozolomide
8. Genetic differences might help distinguish thyroid cancers
9. Evidence builds for potential new cancer drug target
10. New sequence involved in DNA replication timing may aid in cancer detection
11. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2019)... (PRWEB) , ... May 09, 2019 , ... ... of its first suite of products based on its microbubble technology. Unlike magnetic-based ... simply float to the surface. Feedback from customers who participated in an early ...
(Date:5/8/2019)... , ... May 08, 2019 , ... ... Real-Time Metrics (“Axiom”), a premier provider of unified eClinical solutions and services that ... trials and observational studies. Axiom is a leading e-clinical technology company that focuses ...
(Date:5/2/2019)... ... April 30, 2019 , ... Philadelphia intellectual property law firm ... Gunes Bender, Ph.D., a registered patent agent, has joined the firm as a ... Bender provides technical support and scientific expertise in the pharmaceutical and biotechnical arts ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... ... the Diopsys® ffERG/Photopic Negative Response vision test, a new full field ... it is estimated that 6.3 million Americans will have glaucoma, with black Americans ...
(Date:5/2/2019)... ... May 02, 2019 , ... Researchers ... present results documenting discrepancies between U.S. insurer policies for genetic testing and the ... for hereditary breast and ovarian cancer (HBOC). , Jill S. Dolinsky, ...
(Date:4/18/2019)... Mass. (PRWEB) , ... April 18, 2019 , ... ... fossil fuels, a research team that includes a chemical engineer at Worcester Polytechnic ... exotic microorganism that may make it possible to manufacture isobutanol and other biofuels ...
(Date:4/12/2019)... JUPITER, Fla. (PRWEB) , ... April 12, 2019 ... ... will explore recent developments in neurotechnology and will educate about innovative tools and ... 3Q/2019. Check your local listings for more information. , This segment of Advancements ...
Breaking Biology Technology:
Cached News: