HOME >> BIOLOGY >> NEWS
Manipulating a single gene dramatically improves regeneration in adult neurons: Finding may lead to new approaches for treating brain and spinal cord damage

Increasing the expression of a single gene that is important during development dramatically improves the ability of adult neurons to regenerate, a new study shows. The finding suggests that intrinsic properties of neurons play an important role in controlling neuronal regeneration and may lead to new approaches for treating damage from stroke, spinal cord injury, and other neurological conditions.

The study examined how genetically engineering adult neurons to produce larger amounts of a type of protein called integrin affects nerve fiber growth. This approach is one of the first to examine the critical missing half of the regeneration equation: the properties of adult neurons, rather than the environment of the adult brain, says study investigator Maureen L. Condic, Ph.D., of the University of Utah School of Medicine in Salt Lake City. The work was supported by the National Institute of Neurological Disorders and Stroke (NINDS) and will appear in the July 1, 2001, issue of the Journal of Neuroscience.(1)

Most neural regeneration studies in the past have manipulated factors in the environment of the adult nervous system to try to influence neuron growth. Studies have shown that nerve fibers can regenerate in the brain and spinal cord of newborn animals, but regeneration does not normally occur in the brain or spinal cord of older animals. Recent studies have linked neuronal regeneration to integrin proteins, which function as receptors that enable neurons to interact with specialized molecules in the surrounding environment during development. Neurons taken from developing animals typically have very high levels of integrin, but neurons from adult animals have very little of this protein.

In this study, Dr. Condic used a modified adenovirus to insert extra copies of a gene for one kind of integrin protein into sensory neurons taken from adult rats. A second group of neurons received extra copies of a different integrin gene. The a
'"/>

Contact: Natalie Frazin
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
30-Jun-2001


Page: 1 2 3

Related biology news :

1. Manipulating biotope space can enhance beneficial biodiversity effects
2. Recent evolution at a single gene may have brought down heart disease risk in some human groups
3. Basic RNA enzyme research promises single-molecule biosensors
4. Natures ambush: pregnancy more likely from single unprotected intercourse than believed
5. Cell growth and death controlled by single pathway in lymphoma cancer model
6. Is a single bout of exercise helpful or harmful in getting a good nights sleep?
7. Statistical technique helps researchers gain more information from a single data run
8. Ecosystem consequences of a single, genetically based plant trait
9. Changes in shape of single protein plays key role in the spread of cancer cells
10. Ocean life depends on single circulation pattern in Southern Hemisphere
11. Livermore & NIH scientists create technique to examine behavior of proteins at single molecule level

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: