'Man's best friend' may be even better

(June 12 , 2003) Bethesda, MD For millions of Americans, allergic rhinitis, or "hayfever" can lead to severe discomfort, including nasal congestion, difficulty in nasal breathing, and an increase risk for asthma. People with adverse reactions to airborne allergens are often hypersensitive to other irritants such as nitrites, sulfur oxides, airborne particles, and ammonia and co-exposure to air pollutants and allergens may trigger a synergistic response.

Researchers have believed that although histamine and amine compounds released by the cells during an allergic reaction contribute to allergic discomfort, other mediators and neural pathways are also involved. Ideally, identifying the various levels of irritant- and allergen-induced reactions in the nasal passages would provide new insights. To do so, a suitable testing model is necessary to delineate novel target sites and to test potential efficacy and toxicity of new chemical entities before starting evaluations in humans.

Unfortunately, finding the animal model has been a lot more difficult than one would think. Several animal models of rhinitis have been used in previous research but the results were based on euthanizing the animals following the techniques tested, an action unsuitable for application to humans.

A New Study

Now, however, a team of researchers has found that the erstwhile companion of millions -- the friendly beagle dog -- closely resembles the pathophysiology for human allergic rhinitis. This discovery enables the use of experimental techniques similar to those used for the assessment of human nasal passages and permits other, related experiments.

The authors of "Canine Model of Nasal Congestion and Allergic Rhinitis" are Ruslan L. Tiniakov, Olga P. Tiniakova, and Donovan B. Yeates, from the University of Illinois at Chicago, and Veterans Affairs Chicago Health Care System, Chicago, IL; and Robbie L. McLeod and John A. Hey, at the Scheri

Contact: Donna Krupa
American Physiological Society

Page: 1 2 3 4

Related biology news :

1. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
2. Microbes eat their way to better concrete
3. Computer database being developed at Temple will allow for better inventory of chemicals
4. New and better drugs for tuberculosis goal of UH professor
5. Ants protect plants better when jacked up on nectar
6. The blind really do hear better
7. Microarrays, key genome expression trackers, work better when probes are sequence-verified
8. Researchers develop better understanding of immune response to viral infection
9. Crack babies do better when placed with non-family caregivers
10. A better way to copy DNA
11. Gene profiles could improve acute leukemia diagnosis and lead to better treatments

Post Your Comments:

(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: