Mapping the evolution of a virus

has practical application to an important human pathogen, influenza."

Experts estimate that influenza epidemics cause an estimated 500,000 human deaths worldwide each year. Although antibodies provide protective immunity to influenza virus infection, the antigenic structure of proteins that stimulate immune responses changes significantly over time, a process known as antigenic drift, so in most years the influenza vaccine has to be updated to ensure sufficient efficacy against newly emerging variants.

In addition to Lapedes, the team members included Derek Smith from the University of Cambridge, and Ron Fouchi and his colleagues Jan de Jong, Theo Bestebroer, Guus Rimmelzwaan and Albert Osterhaus from National Influenza Center at Erasmus Medical Center.


Contact: Todd Hanson
DOE/Los Alamos National Laboratory

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