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Mathematical prediction of on-off switches in cell division proven

to Leland H. Hartwell, R. Timothy Hunt, and Paul M. Nurse for their discoveries of key regulators of the cell cycle), that cell cycle components are similar in frog and human cells," says Sible.

The researchers' ultimate goal is to build a mathematical model of the human cell cycle that would likewise reveal underlying principles of cell regulation and be predictive. "Many predictions in the model we tested were not intuitive. The belief is that a comprehensive mathematical model of the human cell cycle would present a new understanding of its regulation and suggest novel ways to control disorders such as cancer," says Sible." For example, cell cycle 'checkpoints' guard dividing cells from mistakes that may lead to cancer. Sible continues, "We saw something relevant but subtle in our simple system. If we raised the cyclin level modestly (beyond what was needed to trigger mitosis), we eliminated the checkpoint that normally halts the cell cycle if there is something wrong with the DNA."

Co-authors of the PNAS article are Wei Sha, who completed her master's degree with Sible and is now a Ph.D. student at the Virginia Bioinformatics Institute at Virginia Tech; Jonathan Moore of the Cancer Research United Kingdom London Research Institute; Katherine Chen, a senior research scientist at Virginia Tech; Antonio Lassaletta, an undergraduate student in mechanical engineering who is studying with Sible; and Chung-Seon Yi, a postdoctoral associate with Tyson.


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Contact: Jill Sible
siblej@vt.edu
540-231-1842
Virginia Tech
30-Dec-2002


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