HOME >> BIOLOGY >> NEWS
Max-Planck Researchers Unravel The Structure Of The Methane Forming Enzyme

Max-Planck researchers unravel the structure of the methane forming enzyme

A team of the Max-Planck Institutes from Frankfurt and Marburg has recently determined the structure of methyl-coenzyme M reductase, a key enzyme of methanogenesis that catalyzes a highly complex chemical reaction namely the reduction of a thioether to a hydrocarbon.

Methanogenesis is only carried out by a group of strictly anaerobic microbes called methanogens which use the formation of methane for the purpose of cellular energy generation. Within the microbial ecosystem methanogens participate in the final step of anoxic decomposition of complex organic materials thereby producing about 109 tons of methane per year. The generated methane is either remetabolized by methanotrophic bacteria or escapes to the atmosphere as a potent greenhouse gas. All methanogens are dependent on the enzyme methyl-CoM reductase, a protein complex of 300 kDa size. Its crystal structure was solved to a resolution of 1.45 E which represents the highest resolution for biological macromolecules of that size so far.

Nature has evolved with methyl-coenzyme M reductase a remarkable enzyme composed of six subunits forming a heterohexamer in an (a,_,c)2 arrangement. Three unusual coenzymes are embedded in a 30 E long channel between the subunits. Of particular interest is the binding of coenzyme F430, a Ni-porphinoid which exclusively occurs in this enzyme. As substrates the enzyme binds methyl-coenzyme M (methyl-thioethane sulfonate) and coenzyme B (7-thioheptanoyl threoninephosphate). The highly resolved crystal structure allows a description of the binding modes of these 3exotic2 coenzymes within the protein on an atomic ground.

The biochemical reaction of methyl-coenzyme M reductase proceeds by reducing of methyl-coenzyme M to methane and by oxidizi
'"/>

Contact: Ulrich Ermler
ermler@mpibp-frankfurt.mpg.de
+49-69-96769-384
Max-Planck-Gesellschaft
21-Nov-1997


Page: 1 2

Related biology news :

1. Max-Planck doctoral student discovers living fossils
2. Researchers determine genetic cause of Timothy syndrome
3. Researchers find color sensitive atomic switch in bacteria
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Researchers develop fast track way to discover how cells are regulated
9. Researchers identify distinctive signature for metastatic prostate cancer
10. Researchers report new gene test for isolated cleft lip and palate
11. Researchers discover why mutant gene causes colon cancer

Post Your Comments:
(Date:1/22/2015)... Inc. , a market leader of iris-based identity authentication solutions, ... the new role of Senior Vice President of Mobile and ... platforms and wearable solutions for EyeLock,s technologies. Gerber brings more ... industry to his role at EyeLock, with expertise in human ...
(Date:12/22/2014)... Dec. 22, 2014  The 2014 Holiday Season may be ... Market Intelligence reports that the long anticipated floodgates for ... intensifying demand for smart phones, tablets, and wearable mobile ... of 2.5 billion users with nearly 4.8 billion biometric ...
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis" ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a totally ... for the first time a fingerprint sensor in its ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
(Date:1/22/2015)... Jan. 22. 2015  Varian Medical Systems (NYSE: VAR ... honored for its commitment to sustainability with inclusion on a ... the highest ranked healthcare equipment company among the Corporate Knights ... World Economic Forum at Davos, Switzerland . ...
(Date:12/24/2014)... SPRING, Md. , Dec. 24, 2014  United Therapeutics ... Medtronic, Inc. (NYSE: MDT ) has submitted ... Drug Administration (FDA) for the use of Medtronic,s SynchroMed ... newly developed catheter) for use with United Therapeutics, Remodulin ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ...
(Date:12/24/2014)... MD (PRWEB) December 23, 2014 On ... H.R. 83, the Omnibus and Continuing Resolution Appropriations Act ... a condition eligible to receive funding through the Congressionally ... of Defense (DoD). The Hydrocephalus Association (HA), working in ...
Breaking Biology Technology:Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
Cached News: