HOME >> BIOLOGY >> NEWS
Max-Planck Researchers Unravel The Structure Of The Methane Forming Enzyme

Max-Planck researchers unravel the structure of the methane forming enzyme

A team of the Max-Planck Institutes from Frankfurt and Marburg has recently determined the structure of methyl-coenzyme M reductase, a key enzyme of methanogenesis that catalyzes a highly complex chemical reaction namely the reduction of a thioether to a hydrocarbon.

Methanogenesis is only carried out by a group of strictly anaerobic microbes called methanogens which use the formation of methane for the purpose of cellular energy generation. Within the microbial ecosystem methanogens participate in the final step of anoxic decomposition of complex organic materials thereby producing about 109 tons of methane per year. The generated methane is either remetabolized by methanotrophic bacteria or escapes to the atmosphere as a potent greenhouse gas. All methanogens are dependent on the enzyme methyl-CoM reductase, a protein complex of 300 kDa size. Its crystal structure was solved to a resolution of 1.45 E which represents the highest resolution for biological macromolecules of that size so far.

Nature has evolved with methyl-coenzyme M reductase a remarkable enzyme composed of six subunits forming a heterohexamer in an (a,_,c)2 arrangement. Three unusual coenzymes are embedded in a 30 E long channel between the subunits. Of particular interest is the binding of coenzyme F430, a Ni-porphinoid which exclusively occurs in this enzyme. As substrates the enzyme binds methyl-coenzyme M (methyl-thioethane sulfonate) and coenzyme B (7-thioheptanoyl threoninephosphate). The highly resolved crystal structure allows a description of the binding modes of these 3exotic2 coenzymes within the protein on an atomic ground.

The biochemical reaction of methyl-coenzyme M reductase proceeds by reducing of methyl-coenzyme M to methane and by oxidizi
'"/>

Contact: Ulrich Ermler
ermler@mpibp-frankfurt.mpg.de
+49-69-96769-384
Max-Planck-Gesellschaft
21-Nov-1997


Page: 1 2

Related biology news :

1. Max-Planck doctoral student discovers living fossils
2. Researchers determine genetic cause of Timothy syndrome
3. Researchers find color sensitive atomic switch in bacteria
4. Researchers identify protein promoting vascular tumor growth
5. Researchers devise potent new tools to curb ivory poaching
6. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
7. Researchers ID chlorophyll-regulating gene
8. Researchers develop fast track way to discover how cells are regulated
9. Researchers identify distinctive signature for metastatic prostate cancer
10. Researchers report new gene test for isolated cleft lip and palate
11. Researchers discover why mutant gene causes colon cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/27/2016)... Ohio , Jan. 27, 2016  Rite Track, ... based in West Chester, Ohio ... award winning service staff, based in Austin, ... capacity and ability to provide modifications, installations and technical ... Dovalina , CEO of PLUS, commented, "PLUS has provided ...
(Date:1/22/2016)... DUBLIN , January 22, 2016 ... has announced the addition of the  ... to their offering. --> ... of the  "Global Behavioral Biometric Market ... --> Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ...
(Date:1/20/2016)... , Jan. 20, 2016 A market that ... directly benefit from the explosion in genomics knowledge. Learn ... Sound Research. A range of dynamic trends are pushing ... - personalized medicine - pharmacogenomics - pathogen evolution - ... large markets - greater understanding of the role of ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , February 10, 2016 Early-career researchers ... Peru , Uganda and ... work in health and nutrition   Indonesia , ... Uganda and Yemen are being honored ... epidemiology. They are also celebrated for mentoring young women scientists who are ...
(Date:2/10/2016)... RICHLAND, Wash., Feb. 10, 2016  IsoRay, Inc. (NYSE ... seed brachytherapy and medical radioisotope applications for the treatment ... cancers, today announced its financial results for the second ... December 31, 2015. --> ... second quarter of fiscal 2016, which ended December 31, ...
(Date:2/10/2016)... , ... February 10, 2016 , ... LATHAM, NEW YORK... ... the SPIE Photonics West conference in San Francisco’s Moscone Center from February ... the same venue. , These latest InGaAs PIN diode standard packages feature a ...
(Date:2/10/2016)... Jolla CA (PRWEB) , ... February 10, 2016 , ... ... new agents for the treatment of Alzheimer’s disease, announced today it has been selected ... February 18th at the Breakers in Palm Beach, Florida. The purpose of the ...
Breaking Biology Technology:
Cached News: