HOME >> BIOLOGY >> NEWS
Mayo Clinic develops blood vessel cells from adult progenitor cells

ROCHESTER, Minn. -- Mayo Clinic scientists have shown for the first time that an adult stem cell variant circulating in adult human blood can be driven to form smooth muscle cells, which are key building blocks in blood vessel formation and also participate in coronary artery blockages. The findings are published in this week's edition of Circulation, the journal of the American Heart Association, and will be presented simultaneously at the European Society of Cardiology conference in Berlin.

The researchers used platelet-derived growth factor BB (PDGF-BB) to convert previously undiscovered circulating smooth muscle progenitor cells (SPCs) into smooth muscle outgrowth cells (SOCs). SPCs produced presumably reside in the bone marrow and are stem cells that have started down the path of cell differentiation. Scientists had suspected the existence of circulating SPCs because animal studies had shown that many smooth muscle cells found in atherosclerotic plaques or in restenosis after angioplasty had been partially derived from bone marrow.

The Mayo Clinic study is the first to prove the existence of SPCs in humans. In the presence of PGDF-BB, the cells rapidly proliferated into smooth muscle cells. These cells also had adhesive properties potentially steering the cells to areas of vessel blockages. According to first author, David Simper, M.D., the study may be a significant step in the potential development of new vessels (angiogenesis) to provide blood circulation to diseased hearts. "Previous studies have shown that endothelial cells, which line blood vessels can be grown from progenitors in blood," says Dr. Simper. "Smooth muscle cells are the essential building blocks of arteries, and until now we have not had a way to create them".

These new findings may help cardiologists address in a new way some of the key problems in interventional cardiology. "About 30 percent of patients with heart disease who have stents implanted during a
'"/>

Contact: Lee Aase
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
3-Sep-2002


Page: 1 2

Related biology news :

1. Creation of the UK Clinical Research Collaboration will boost clinical trials in UK
2. Hope Clinic of Emory Vaccine Center receives CDC contract
3. Clinical judgement still counts strongly alongside genetic testing
4. Jay Levy honored with 2004 Abbott Laboratories Award in Clinical and Diagnostic Immunology
5. Melvin Weinstein wins 2004 BD Award for Research in Clinical Microbiology
6. St. Jude/Mayo Clinic study finds direct link between CBP gene and lymphoma
7. DFG to establish seven new Clinical Research Units
8. Clinical trial patients dont care about study sponsors or physician conflicts of interest
9. NIH establishes Rare Diseases Clinical Research Network
10. Grant strengthens research arm of Penn State Hershey Medical Centers ALS Clinic
11. Clinical study reports findings of combination therapy with DOXIL

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mayo Clinic develops blood vessel cells from adult progenitor cells

(Date:3/23/2015)... Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market, announces its biometric payment technology, ... on CNBC television starting March 30 th . ... in New York markets. ... are excited about our new ad campaign following the recent ...
(Date:3/19/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... this week on Washington DC,s Fox ... segment "The Next Great Thing", host Laura Evans ... and ,a really big breakthrough in mobile payment.,  ...
(Date:3/16/2015)... HANOVER, Germany , March 16, 2015 /PRNewswire/ ... DERMALOG Identification Systems GmbH will present groundbreaking innovations ... Hanover, Germany . ... DERMALOG,s latest biometric innovation is well at ... the next generation e-gate made in ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
(Date:3/27/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the global pharmaceutical, biotechnology, ... Investigational New Drug (IND) application for WuXi MedImmune,s ... been accepted for review by the China Food ... September 2012, MedImmune, the global biologics research and ...
(Date:3/26/2015)... WARREN, N.J., March 26, 2015  Roka Bioscience, ... company focused on providing advanced testing solutions for ... financial results for the three months and full ... Quarter 2014 Financial Results:Revenue for the quarter ended ... $689,000 for the fourth quarter of 2013 and ...
(Date:3/26/2015)... CO (PRWEB) March 26, 2015 The ... has formed a strategic alliance with Designing Gig LLC ... their clients. , “Forging this alliance with ... Now we can extend a comprehensive, end-to-end, digital ... development, strategy, and execution,” said Chuck Miller, president of ...
(Date:3/26/2015)... Corporation (NASDAQ: NEOG ) announced today that its ... which ended Feb. 28, increased 13% to $7,454,000, when ... in the current quarter were $0.20, compared to $0.18 ... over prior year to $24,142,000, or $0.65 per share, ... same period a year ago. Revenues for ...
Breaking Biology Technology:Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8
Cached News: