HOME >> BIOLOGY >> NEWS
Mayo Clinic develops blood vessel cells from adult progenitor cells

ROCHESTER, Minn. -- Mayo Clinic scientists have shown for the first time that an adult stem cell variant circulating in adult human blood can be driven to form smooth muscle cells, which are key building blocks in blood vessel formation and also participate in coronary artery blockages. The findings are published in this week's edition of Circulation, the journal of the American Heart Association, and will be presented simultaneously at the European Society of Cardiology conference in Berlin.

The researchers used platelet-derived growth factor BB (PDGF-BB) to convert previously undiscovered circulating smooth muscle progenitor cells (SPCs) into smooth muscle outgrowth cells (SOCs). SPCs produced presumably reside in the bone marrow and are stem cells that have started down the path of cell differentiation. Scientists had suspected the existence of circulating SPCs because animal studies had shown that many smooth muscle cells found in atherosclerotic plaques or in restenosis after angioplasty had been partially derived from bone marrow.

The Mayo Clinic study is the first to prove the existence of SPCs in humans. In the presence of PGDF-BB, the cells rapidly proliferated into smooth muscle cells. These cells also had adhesive properties potentially steering the cells to areas of vessel blockages. According to first author, David Simper, M.D., the study may be a significant step in the potential development of new vessels (angiogenesis) to provide blood circulation to diseased hearts. "Previous studies have shown that endothelial cells, which line blood vessels can be grown from progenitors in blood," says Dr. Simper. "Smooth muscle cells are the essential building blocks of arteries, and until now we have not had a way to create them".

These new findings may help cardiologists address in a new way some of the key problems in interventional cardiology. "About 30 percent of patients with heart disease who have stents implanted during a
'"/>

Contact: Lee Aase
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
3-Sep-2002


Page: 1 2

Related biology news :

1. Creation of the UK Clinical Research Collaboration will boost clinical trials in UK
2. Hope Clinic of Emory Vaccine Center receives CDC contract
3. Clinical judgement still counts strongly alongside genetic testing
4. Jay Levy honored with 2004 Abbott Laboratories Award in Clinical and Diagnostic Immunology
5. Melvin Weinstein wins 2004 BD Award for Research in Clinical Microbiology
6. St. Jude/Mayo Clinic study finds direct link between CBP gene and lymphoma
7. DFG to establish seven new Clinical Research Units
8. Clinical trial patients dont care about study sponsors or physician conflicts of interest
9. NIH establishes Rare Diseases Clinical Research Network
10. Grant strengthens research arm of Penn State Hershey Medical Centers ALS Clinic
11. Clinical study reports findings of combination therapy with DOXIL

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mayo Clinic develops blood vessel cells from adult progenitor cells

(Date:2/5/2015)... PARK, North Carolina , 5. Februar ... 35. Jahr als spezialisiertes Logistikunternehmen und hat ... als einzige klinische Logistikfirma (Clinical Logistics Organization ... Kernbotschaft der neuen Kampagne lautet First ... Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... , January 28, 2015 New ... Size And Segment Forecasts To 2020 has Been Added ... camera market is expected to reach USD 5.10 billion ... View Research, Inc. IR cameras help identify the site ... expected to witness surging demand in medical imaging applications. ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the ... report to their offering. , The ... individual is who she/he is claiming to be, and for ... unique physical characteristics, such as fingerprint, hand or palm print, ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
(Date:2/27/2015)... 27, 2015 Cytokinetics, Incorporated (Nasdaq: CYTK) ... 28 with patients and health care advocates in the ... Disease Day®. Rare Disease Day is dedicated to ... to the special challenges faced by patients with rare ... is proud to stand alongside patients and caregivers representing ...
(Date:2/26/2015)... MOUNTAIN VIEW, Calif. , Feb. 26, 2015 /PRNewswire/ ... appointment of Kate Black as Privacy Officer ... international, federal, and state privacy laws as well as ... and regulatory team, she will be responsible for reviewing, ... for customers in the U.S. and abroad. She joined ...
(Date:2/26/2015)... Fla. , Feb. 26, 2015 DuPont ... growth priorities driven by key research advancements and product ... at today,s Bank of America Merrill Lynch 2015 Global ... the challenge of building grain supplies the last two ... continue at the pace of the last decade, when ...
(Date:2/26/2015)... BioEnterprise today announced that Northeast Ohio ... in growth funding during the past 13 years.  Funding ... – including the Ohio Third Frontier - and federal ... raised in the past five years. ... BioEnterprise Midwest Healthcare Growth Capital  Report.   ...
Breaking Biology Technology:Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 2Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 3Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 4Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 5Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 623andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4
Cached News: