HOME >> BIOLOGY >> NEWS
McGill scientists publish detailed picture of how nutrients and other molecules get into cells

Montreal, March 9, 2004. Scientists at the Montreal Neurological Institute and the Montreal Proteomics Network at McGill University have published the most complete picture to date of the components of the molecular machinery that controls the entry of nutrients and other molecules into cells. In a study published in the Proceedings of the National Academy of Sciences of the USA (PNAS), Dr. Peter McPherson and colleagues used proteomics, the large-scale study of proteins, to identify the protein complement of clathrin-coated vesicles. These vesicles are the vehicles by which cells are able to take up nutrients, such as cholesterol, from their environment. Defects in this uptake process have profound repercussions on cellular function and human health. For example, genetic diseases that lead to deficiencies in cholesterol uptake cause elevations in plasma cholesterol levels and early-onset coronary atherosclerosis. In the brain, problems in the uptake process involving clathrin-coated vesicles can disrupt the transmission of signals between nerve cells. This can lead to a number of disorders including defects in the ability to form new memories.

"Proteins are the workhorses in our cells," explained Dr. McPherson, Associate Professor of Neurology and Neurosurgery, and Anatomy and Cell Biology at the Montreal Neurological Institute (MNI) at McGill University. "Increasingly, we are learning that proteins don't work in isolation, but function in large arrays that form protein machines. Proteomics is exciting because it allows us to breakdown this complex machine into its component parts. We can then figure out how it is assembled, how the proteins interact with one another, and what goes wrong in disease.

"The study from Dr. McPherson and his colleagues is fundamental to our understanding of the cellular uptake process because it provides a comprehensive molecular inventory of the clathrin-coated vesicle. Its results have broad implications
'"/>

Contact: Sandra McPherson
sandra.mcpherson@mcgill.ca
514-398-1902
McGill University
9-Mar-2004


Page: 1 2

Related biology news :

1. McGill Centre for Intellectual Property Policy receives $3 million SSHRC Grant
2. MNI-McGill researcher first to discover that normal nerve cells can mimic viruses
3. New McGill researchers win recognition
4. McGill launches Centre for Bioinformatics
5. McGill team offers new hopes in cures for Parkinsons disease, schizophrenia, depression, drug addiction and severe pain
6. Nonchemical weedkiller has huge potential; hungriest nations may benefit thanks to McGill plant scientists
7. Major grant to aid McGill University professors efforts to improve school science teaching
8. DNA lends scientists a hand, revealing new chemical reactions
9. Conference at UH opens doors for new scientists, engineers
10. Wisconsin scientists develop quick botox test
11. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... RESTON, Va. (PRWEB) , ... August 14, 2018 ... ... stigmas were recently depicted in the movie “Wonder,” to a better understanding of ... defects treatments, according to editors of the latest special issue of Birth ...
(Date:8/7/2018)... EDWARDSVILLE, Ill. (PRWEB) , ... August 06, 2018 ... ... corn growing in front of The NCERC at Southern Illinois University Edwardsville’s University ... corn, but also grain sorghum and sweet sorghum. These three feedstocks represent conventional ...
(Date:8/2/2018)... ... August 02, 2018 , ... The ... innovator Boston Heart Diagnostics to its Lifestyle Medicine Corporate Roundtable, a group of ... care system and a sustainable world. , Boston Heart is transforming the ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... MATEO, Calif. (PRWEB) , ... July 25, 2018 ... ... for in vivo research utilizing its state-of-the-art Digital Vivarium™ and Vium Cloud approach ... Schaevitz, Ph.D., to Chief Scientific Officer. Additionally, the company announced the appointment of ...
(Date:7/25/2018)... ... July 25, 2018 , ... John McDonald, CEO ... board of the Indiana India Business Council (IIBC), an advocacy group to strengthen ... current board of directors, McDonald joins an impressive roster of local and national ...
(Date:7/24/2018)... ... July 24, 2018 , ... Boval was founded in 1978 ... reagent suppliers. In Boval’s early days most of the BSA manufactured was for ... BSA for diagnostic purposes after gel cards changed that market and displaced most of ...
(Date:7/22/2018)... ... July 19, 2018 , ... Mitotech ... with Essex Bio-Investment for Phase 3 clinical program in Dry Eye Disease. Under ... SkQ1 with approximately $17m allocated towards the first Phase 3 study starting as ...
Breaking Biology Technology:
Cached News: