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McLean Hospital and Repligen announce results of brain imaging study of secretin

NOTE: This release has been udpated from its original posting.

Belmont and Waltham, MA November 1, 2002 Researchers from the Brain Imaging Center at McLean Hospital and Repligen Corporation (Nasdaq: RGEN) reported today the results of a clinical trial designed to assess the neurological activity of secretin by functional magnetic resonance imaging (fMRI). The results demonstrate for the first time in humans, that secretin is active in the central nervous system and that it potentiates activity in the amygdala, a region of the brain involved in social integration and implicated in autism. The findings were presented today by Deborah Yurgelun-Todd, Ph.D., of McLean Hospital, the study's Principal Investigator, at the International Meeting for Autism Research, a satellite meeting of the Society for Neuroscience.

"Our results demonstrate for the first time that secretin is a neuroactive peptide in humans and that it acts on a brain region known to be important for social interaction," stated Yurgelun-Todd, Director of Cognitive Neuroimaging at the Brain Imaging Center at McLean Hospital. "These findings suggest that secretin may have a role in modulating certain social behavior in humans."

The study was a double-blind, placebo-controlled clinical trial in 12 healthy men. Each subject was presented with a series of pictures of faces with either a neutral, happy or fearful facial expression to establish a baseline response. Following an injection of either secretin or a placebo, the subjects were again presented with the series of facial expressions. Throughout the experiment, the activation of the amygdala was recorded with MRI. There was a significant activation (p=0.001) of the right amygdala by secretin when the subjects viewed pictures of a fearful face compared to both the placebo group and the baseline response to the pictures in the secretin group. By contrast, there was no difference in amygdala activation when subjects viewed pic
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Contact: Renee L. Connolly
renee.connolly@nrp-euro.com
212-845-4254
Noonan/Russo Communications
1-Nov-2002


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