Mechanical forces found to exert larger role in blood vessel health and disease

University Park, Pa. --- Cholesterol, dietary fat, drugs and other chemical bio-regulators may get most of the media attention, but Penn State engineers have shown that mechanical forces, including shear stress, stretch and pressure, can play unsuspected but equivalent roles in some aspects of cardiovascular health and disease.

Dr. John Tarbell, distinguished professor of chemical engineering, and associates in Penn State's Biomolecular Transport Dynamics Laboratory, recently showed that there is a one-to-one correspondence between certain effects of shear stress, the frictional force exerted by blood flow, and a growth factor that stimulates the production of new blood vessels. The Penn State group compared the effects of shear stress with that of vascular endothelial growth factor (VEGF) in laboratory tests with both human and bovine blood vessel tissue. VEGF is multifunctional and, in addition to promoting the growth of new blood vessels, it affects the ability of the cells on the interior surface of blood vessels, the endothelium, to allow fluid to pass through to the cells beneath.

The researchers showed that shear stress and VEGF not only cause similar changes in endothelium transport properties but also do so by the same chemical signaling pathways. Each of the tissue types the group investigated produces nitric oxide in response to shear stress, and nitric oxide is believed to be a key intermediate in the cell signaling cascade for both shear stress and VEGF, according to their recent paper.

Tarbell, who directs Penn State's Biomolecular Transport Dynamics Option for graduate study in the Life Sciences Consortium, notes that his group also investigates the effects of fluid flow as it passes across blood vessel walls. This transmural flow is six orders of magnitude or a million times slower than blood flow and amounts to a "seepage" through the wall's tissue matrix.

Nevertheless, even though the flow is slow, Tarbell and his assoc

Contact: Barbara Hale
Penn State

Page: 1 2

Related biology news :

1. Future uses of MicroElectricalMechanical (MEM) systems to be featured at Santa Clara show
2. East Asian governments urged to harness market forces to improve environment, save money
3. NYAS and Nature Publishing Group join forces
4. Foundations join forces to find a cure or treatment for deadly genetic disease
5. Foundations join forces to finance research for Canavan disease
6. Whats next as biology, math combine forces, reciprocate in discovery
7. Fluid forces within the body help invasive bacteria
8. Disorder forces DNA molecules out of tight spaces
9. Immunex Corporation and Genentech, Inc. join forces to develop TRAIL/Apo2L in cancer
10. New signs of life found at the Poles
11. Key cell-death step found

Post Your Comments:

(Date:7/31/2020)... ... July 30, 2020 , ... ... Phase II contract awarded by the Joint Science & Technology Office—Chemical and Biological ... is to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess ...
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... ... that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise control device ... The study reported that the Neoasis™ device attenuated the alarm sounds from patient ...
(Date:7/10/2020)... ... 2020 , ... Today CJ BIO announced the first in a series of ... taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a ... July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced ... Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the ... awards program, highlighting outstanding examples of how technology innovations and strategic initiatives can ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... that the launch of a new clinical diagnostics immuno-oncology service, TissueInsight ... microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
(Date:6/23/2020)... ORLANDO, Fla. (PRWEB) , ... June 23, 2020 ... ... proximity enabled solutions in complex indoor environments, announced today that Derek Fournier has ... the role of Chairman of the Board, effective immediately. , “DeCurtis Corporation ...
Breaking Biology Technology:
Cached News: