Mechanism For Fungal Adherence Found, Possible Key To Disease

professor of medical microbiology and immunology at Ohio State University, and Janet Staab, a postdoctoral fellow in the same department, wanted to discover how Candida can become so prolific.

The organism usually grows in yeast form by budding. But when conditions are right -- as they are in the human body in immune-suppressed patients -- Candida albicans grows by sending off filaments, spreading across and penetrating into epithelial, or skin, cells like ivy across the backyard. Sundstrom focused their research on how these filaments were able to adhere so strongly to the mucosal epithelial cells, fostering the filaments' growth.

"We believe that the purpose of this adhesion is simply so that the organism can stay put and not be washed away by fluids within the GI tract," she said. "The invasive behavior of these filaments caused me to start looking for specific proteins in the Candida filaments when I was a graduate student at the University of Washington in Seattle."

Earlier work had led her to identify a specific gene responsible for producing a protein that can become linked to other proteins using an enzyme called transglutaminase. The protein serves as a substrate, or anchor, upon which the enzyme can build larger, essential molecules.

Transglutaminases are well-known mammalian enzymes, although they are rare or absent in fungi. But in Candida, the rese

Contact: Paula Sundstrom
Ohio State University

Page: 1 2 3 4 5

Related biology news :

1. Mechanism controls movement of cell structures
2. Mechanism to overcome Gleevec resistance demonstrated
3. Mechanism that enables fetus to survive in mother under study
4. Mechanism believed found that regulates movement within cells
5. Mechanism for generating autoimmunity-suppressing cells identified
6. Mechanism found that appears to keep body tissues together
7. Discovery Of Mechanism Causing Colon Cancer
8. Researchers Discover Mechanism Of Cleft Palate Development
9. The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms
10. Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
11. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: