HOME >> BIOLOGY >> NEWS
Mechanism For Fungal Adherence Found, Possible Key To Disease

archers found a protein that also bound to transglutaminase.

"We wondered why Candida would have a substrate protein for these mammalian enzymes," Sundstrom said. "We're talking about a fungal protein that is a substrate for a mammalian enzyme. This enzyme is special since it can cross-link proteins together, two different proteins. Most enzymes don't do that."

They discovered that when the protein in the fungi filaments uses the enzyme to link to the protein in the epithelial cells, it forms a covalent bond -- the strongest type possible -- giving it great adhesive capabilities. This type of covalent adhesion has not been described previously in any viruses, bacteria, fungi or other microorganisms.

Several years ago, S.D. Bradway, a former assistant professor of periodontology at Ohio State and co-author on this paper, showed that Candida albicans could form stable attachments. However, that work did not identify what proteins were involved.

Sundstrom's group used a strain of Candida in which the transglutaminase-binding protein had been removed and tested its ability to adhere to human oral mucosal cells. Without the protein, there was a five-fold reduction in the ability of Candida to attach. When the gene was replaced, stable attachments were again formed. This proved that Sundstrom's newly discovered gene was a key in the fungus" abi
'"/>

Contact: Paula Sundstrom
Sundstrom.1@osu.edu
614-292-6252
Ohio State University
5-Mar-1999


Page: 1 2 3 4 5

Related biology news :

1. Mechanism controls movement of cell structures
2. Mechanism to overcome Gleevec resistance demonstrated
3. Mechanism that enables fetus to survive in mother under study
4. Mechanism believed found that regulates movement within cells
5. Mechanism for generating autoimmunity-suppressing cells identified
6. Mechanism found that appears to keep body tissues together
7. Discovery Of Mechanism Causing Colon Cancer
8. Researchers Discover Mechanism Of Cleft Palate Development
9. The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms
10. Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
11. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: