HOME >> BIOLOGY >> NEWS
Mechanism Of Protein Folding Unraveled, With Eventual Implications For Treating,,Diseases Caused By Folding Errors

The process of how a protein changes from an initially shapeless string of amino acids to a three-dimensional structure with nooks and crannies of biologically active sites is often called the second half of the genetic code. This transformation is called protein folding.

Research at the University of Pennsylvania Medical Center has recently added some revealing clues as to how this conversion is managed and corrects some misconceptions about how rapidly folding occurs. This active area of research has taken on even more importance with the growing knowledge that errors in protein folding can lead to such deadly and debilitating disorders as Alzheimer's disease, Huntington's-related diseases, and prion-related encephalopathies. A report on this study appears in today's issue of Nature Structural Biology.

How a protein manages to fold is a seemingly impossible problem, suggests S. Walter Englander, PhD, a professor of biochemistry and biophysics at the University of Pennsylvania School of Medicine: "Even with a small, 100-amino-acid-long protein, the number of possible three-dimensional structures that the protein might manifest is larger than the number of molecules in the universe." Protein biologists believe that the amino-acid sequences laid out by the genetic machinery contain chemical instructions for the pathway that carries each protein to its final structure.

The Penn experiments show that the amino-acid chain progresses through a series of pre-determined, intermediate arrangements. Englander's lab has demonstrated that the protein cytochrome c builds its structure in steps by first making helices at either end that lay at right angles to each other. Then, strands, loops, and other helices build up against that initial foundation until the final arrangement is reached. All this can occur in less than one second, but trouble can arise along the way. "A few years ago we showed that on the complicated journey to their fina
'"/>

Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
215-614-0290
University of Pennsylvania School of Medicine
1-Oct-1998


Page: 1 2

Related biology news :

1. Mechanism controls movement of cell structures
2. Mechanism to overcome Gleevec resistance demonstrated
3. Mechanism that enables fetus to survive in mother under study
4. Mechanism believed found that regulates movement within cells
5. Mechanism for generating autoimmunity-suppressing cells identified
6. Mechanism found that appears to keep body tissues together
7. Discovery Of Mechanism Causing Colon Cancer
8. Researchers Discover Mechanism Of Cleft Palate Development
9. The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms
10. Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
11. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2019)... ... January 03, 2019 , ... ... cell culture models into their drug discovery research workflows with biology ranging from ... in vivo relevancy of in vitro studies, they create several challenges that need ...
(Date:12/27/2018)... ... December 27, 2018 , ... uBiome, the leader in microbial ... JP Morgan 37th Annual Healthcare Conference in San Francisco, which brings together industry ... community. , Since its origin in 1983, the JP Morgan Healthcare Conference ...
(Date:12/20/2018)... TRIANGLE PARK, N.C. (PRWEB) , ... December 20, ... ... have been enhanced through upgraded processes and the completion of a new usability/observation ... Evaluations with the goal of ensuring medical devices and drug delivery devices/combination products ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... ... 2018 , ... Microbial Discovery Group LLC (MDG) has expanded ... of their strategic plan and an important milestone in increasing their Bacillus fermentation ... MDG within the $44 Billion human probiotic market. This plan is a vital ...
(Date:12/5/2018)... ZOETERMEER, Netherlands (PRWEB) , ... December 05, 2018 , ... ... last week paid tribute to in the European Parliament by Carlos Moedas, the European ... High-Level Conference EU Research and Innovation in Our Daily Lives, Commissioner Moedas spoke at ...
(Date:11/29/2018)... ... ... RAGS, today announced the closing of a $1.5 million Second Seed round investment. ... board member Jeremy Andrus, CEO of Traeger Grills, as well as James Ho of ... to accelerate its growth and expand the product line. RAGS has now raised a ...
(Date:11/26/2018)... ... 2018 , ... USARAD Holdings Inc., the leading US Joint ... Radiologic founders) among other healthcare investors exhibits at the Radiological Society of North ... The company is proud to announce a 10 year anniversary since its formation ...
Breaking Biology Technology:
Cached News: