HOME >> BIOLOGY >> NEWS
Mechanism Of Protein Folding Unraveled, With Eventual Implications For Treating,,Diseases Caused By Folding Errors

The process of how a protein changes from an initially shapeless string of amino acids to a three-dimensional structure with nooks and crannies of biologically active sites is often called the second half of the genetic code. This transformation is called protein folding.

Research at the University of Pennsylvania Medical Center has recently added some revealing clues as to how this conversion is managed and corrects some misconceptions about how rapidly folding occurs. This active area of research has taken on even more importance with the growing knowledge that errors in protein folding can lead to such deadly and debilitating disorders as Alzheimer's disease, Huntington's-related diseases, and prion-related encephalopathies. A report on this study appears in today's issue of Nature Structural Biology.

How a protein manages to fold is a seemingly impossible problem, suggests S. Walter Englander, PhD, a professor of biochemistry and biophysics at the University of Pennsylvania School of Medicine: "Even with a small, 100-amino-acid-long protein, the number of possible three-dimensional structures that the protein might manifest is larger than the number of molecules in the universe." Protein biologists believe that the amino-acid sequences laid out by the genetic machinery contain chemical instructions for the pathway that carries each protein to its final structure.

The Penn experiments show that the amino-acid chain progresses through a series of pre-determined, intermediate arrangements. Englander's lab has demonstrated that the protein cytochrome c builds its structure in steps by first making helices at either end that lay at right angles to each other. Then, strands, loops, and other helices build up against that initial foundation until the final arrangement is reached. All this can occur in less than one second, but trouble can arise along the way. "A few years ago we showed that on the complicated journey to their fina
'"/>

Contact: Karen Young Kreeger
kreeger@mail.med.upenn.edu
215-614-0290
University of Pennsylvania School of Medicine
1-Oct-1998


Page: 1 2

Related biology news :

1. Mechanism controls movement of cell structures
2. Mechanism to overcome Gleevec resistance demonstrated
3. Mechanism that enables fetus to survive in mother under study
4. Mechanism believed found that regulates movement within cells
5. Mechanism for generating autoimmunity-suppressing cells identified
6. Mechanism found that appears to keep body tissues together
7. Discovery Of Mechanism Causing Colon Cancer
8. Researchers Discover Mechanism Of Cleft Palate Development
9. The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms
10. Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
11. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2019)... (PRWEB) , ... March 18, 2019 , ... ... cost-effective, but also successfully leverages the patient perspective and improves participation by better ... is one way of involving the patient in the entire process from development ...
(Date:3/13/2019)... N.J. (PRWEB) , ... March 13, 2019 , ... ... for the Pharmaceutical, Biotechnology and Medical Device Industries, is excited to announce that it ... in early February 2019 and the newly installed and highly experienced management team ...
(Date:3/9/2019)... ... March 07, 2019 , ... A firm believer in causes ... & Lymphoma Society (LLS). This donation will help fund not only research to find ... families. , “We are always on the lookout for ways to make a ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... , ... March 19, 2019 , ... ... Inc. (Konica Minolta) today announced the formation of their inaugural Scientific Advisory Board. ... of precision medicine that takes into account individual variability in genes, environment, and ...
(Date:3/18/2019)... BARBARA, Calif. (PRWEB) , ... March 18, 2019 , ... ... have partnered together to develop solutions that allow life science companies to easily comply ... requirements. USDM’s Cloud Assurance ™ is a managed service delivering end-to-end GxP compliance ...
(Date:3/14/2019)... ... March 14, 2019 , ... Open ... themed “Navigating the Full Spectrum of Case Management,” continues as CMSA makes plans ... conference is the only case management industry conference serving the educational and networking ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... solution for preclinical research organizations. It is a low code, GDPR/21 CFR ... and facilities, innovative technology-driven automated data capture and seamless data and information ...
Breaking Biology Technology:
Cached News: