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Mechanism believed found that regulates movement within cells

organelle, Gelfand said. When the motor is off, there is nothing there. The motor is in neutral, as if a clutch is pushed. We wanted to know why the motor disengages.

The answer was the smaller protein, known as calcium/calmodulin-dependent protein kinase II (CaMKII). A series of experiments clearly showed that CaMKII is the clutch in a variety of scenarios involving myosin-V, Gelfand said. The two proteins are often found together in laboratory analyses.

It is possible that CaMKII regulates myosin-V functions in neurons with the same basic mechanism that is described here for pigment cells, the researchers wrote in their conclusion.


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Contact: Jim Barlow
b-james3@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
17-Aug-2001


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