Mechanism for generating autoimmunity-suppressing cells identified

PHILADELPHIA Autoimmune disorders, such as lupus, arthritis, and diabetes, are understood to result from immune cells attacking the bodys own cells instead of infectious agents such as viruses and bacteria. In a new study, scientists at The Wistar Institute have identified for the first time the mechanism by which the immune system generates regulatory T cells, a specialized type of immune cell that plays a critical role in preventing autoimmunity.

The findings suggest that regulatory T cells are finely tuned toward the recognition of the bodys own proteinsor selfand that a failure to make a complete repertoire of regulatory T cells may be an important factor in the development of autoimmune disease. In addition, the study suggests that engineering different types of regulatory T cells in the laboratory could one day become a strategy for combating autoimmune diseases.

The research is published in the April issue of Nature Immunology.

We and others showed previously that regulatory T cells suppress autoimmunity, but it was unknown how these cells were generated, says Andrew J. Caton, Ph.D., associate professor at The Wistar Institute and senior author on the study. Now, we believe we have good insight into that process.

Caton says the prevailing belief has been that the developing T cells most highly reactive to and specific for self proteins are eliminated by the body, and that developing T cells that are somewhat less specifically reactive to self are recruited for the regulatory function. Our findings contradict that notion and suggest that regulatory T cells recognize self proteins by a highly specific process, he says.

Research published last year by the same laboratory reported that as many as 10 percent of T cells in a normal animal are regulatory T cells, indicating their importance as a safeguard against autoimmunity.

Whats interesting about these regulato

Contact: Marion Wyce/Franklin Hoke
The Wistar Institute

Page: 1 2

Related biology news :

1. Mechanism controls movement of cell structures
2. Mechanism to overcome Gleevec resistance demonstrated
3. Mechanism that enables fetus to survive in mother under study
4. Mechanism believed found that regulates movement within cells
5. Mechanism found that appears to keep body tissues together
6. Discovery Of Mechanism Causing Colon Cancer
7. Researchers Discover Mechanism Of Cleft Palate Development
8. The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms
9. Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
10. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms
11. Mechanism For Fungal Adherence Found, Possible Key To Disease

Post Your Comments:

(Date:6/6/2019)... ... June 05, 2019 , ... Pelican BioThermal ... network station and service center in Mexico City, Mexico. Mexico is the second ... with more than $1.75 billion in pharmaceutical exports since 2015. The Mexico City ...
(Date:6/4/2019)... , ... June 04, 2019 , ... ... announced the appointment of Susan Murphy as the new President of Molecular Devices, ... by Molecular Devices’ parent company, Danaher Corporation. , Since joining Molecular Devices in ...
(Date:6/4/2019)... DIEGO (PRWEB) , ... June 04, 2019 , ... Lajollacooks4u ... of Fame recipients. The recognition, which honors hospitality excellence, is given only to businesses ... Certificate of Excellence for five consecutive years. , To qualify for the ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, Inc., ... strategic acquisition of Metabiologics, Inc., a globally recognized leader in the production and ... commercialization rights to a full spectrum of botulinum neurotoxins, as well as a ...
(Date:5/21/2019)... ... May 21, 2019 , ... DuPont Nutrition & ... the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, strengthening relationships and ... which is supported through a partnership with “Ethiopia Invest”, will run through May ...
(Date:5/14/2019)... ... May 13, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ ... The redesigned website aims to improve LDA’s ability to communicate directly with the ...
(Date:5/7/2019)... ... May 06, 2019 , ... "The ... growing number of repositories being asked to store cellular products being used ... of contributors who are world leaders, who have shared their expertise in building ...
Breaking Biology Technology:
Cached News: