HOME >> BIOLOGY >> NEWS
Mechanism found that appears to keep body tissues together

CHAMPAIGN, Ill. - Scientists studying the adhesive properties of cadherin - a protein that binds cells into soft tissue - have found a built-in safety mechanism that may keep cells from ripping apart. "Cadherins hold soft tissues together by binding to identical proteins on adjacent cell surfaces," said Deborah Leckband, a professor of chemical engineering at the University of Illinois. "The resulting strong, intercellular junctions play an important role in holding our tissues together. The proteins are also important in facilitating the cell-sorting process during embryonic development."

Because there are a number of diseases "associated with malfunctions or mutations of the cadherin protein," Leckband said, "a better understanding of how these molecules bind to one another may eventually allow the use of gene therapy to devise potential cures." To study the adhesive properties of cadherin, Leckband and her colleagues used a surface-force apparatus to measure the molecular forces between two cadherin monolayers as a function of the distance between them. Leckband's colleagues were graduate student Sanjeeve Sivasankar and postdoctoral research associate Nicolay Lavrik at the U. of I., and graduate student Bill Brieher and molecular biologist Barry Gumbiner at the Memorial Sloan-Kettering Cancer Center in New York City.

"Our direct-force measurements show that the current model for cadherin is insufficient to explain how this protein binds to its neighbors," Leckband said. "We found that the proteins adhere strongest when they overlap completely; not when just their ends touch, as the model had suggested. In fact, our measurements indicate that the ends of the proteins contribute very little to the binding process."

One of the scientists' most surprising findings, however, was the unusual way in which the proteins detached from one another. "Instead of simply snapping apart, the cadherins first moved apart slowly, then built up speed and finall
'"/>

Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
(217) 244-1073
University of Illinois at Urbana-Champaign
13-Oct-1999


Page: 1 2

Related biology news :

1. Mechanism controls movement of cell structures
2. Mechanism to overcome Gleevec resistance demonstrated
3. Mechanism that enables fetus to survive in mother under study
4. Mechanism believed found that regulates movement within cells
5. Mechanism for generating autoimmunity-suppressing cells identified
6. Discovery Of Mechanism Causing Colon Cancer
7. Researchers Discover Mechanism Of Cleft Palate Development
8. The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms
9. Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
10. Reversible Process For Forming Supramolecular Polymers Could Be The Basis Of Fibers, Molecular Transport Mechanisms
11. Mechanism For Fungal Adherence Found, Possible Key To Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... 28, 2018 , ... Today, Bright Computing , a ... Science Technologies has implemented Bright Cluster Manager at the HudsonAlpha Institute for Biotechnology. ... and genetics research institute located in Huntsville, Ala. Its mission is four-fold: genomic ...
(Date:8/26/2018)... ... August 23, 2018 , ... ... increased sensitivity and specificity over more commonly used analytical techniques. However, implementation can ... burden of development and validation of methods that must be undertaken by the ...
(Date:8/23/2018)... ... August 21, 2018 , ... ... diverse cell types and species for the robust functional interrogation of complex biological ... development of T-cell based immunotherapies, the study of the autoimmunity, the understanding of ...
Breaking Biology News(10 mins):
(Date:9/12/2018)... Calif. and VIENNA, Austria (PRWEB) , ... September 10, 2018 , ... ... leading supplier of Semantic Graph Database technology, AllegroGraph , for Knowledge Graphs, and ... leading provider of Semantic AI solutions, today announced a partnership to develop the ...
(Date:9/7/2018)... ... September 06, 2018 , ... The ... is a meeting of “The industry’s preeminent event on novel drug targets.” BellBrook ... powerful tools to study these emerging targets in a quest to find new ...
(Date:8/31/2018)... ... 2018 , ... A recent expedition led by Dr. Blair ... of Industrial Science, the University of Tokyo, demonstrated how the use of autonomous ... of hard to reach deep sea ecosystems, like intermittently active methane seeps. Thanks ...
(Date:8/29/2018)... ... August 28, 2018 , ... CEO and founder ... safety study performed on an allogeneic (donor derived) stem cell product for osteoarthritis ... conference in September. He is also the organizer of Breakout Session 4: ...
Breaking Biology Technology:
Cached News: