Medimmune and Critical Therapeutics to co-develop treatments for severe inflammatory diseases

GAITHERSBURG, MD and CAMBRIDGE, MA, July 31, 2003 MedImmune, Inc. (Nasdaq: MEDI) and Critical Therapeutics, Inc. (CTI), a private biopharmaceutical company, today announced the signing of an agreement to co-develop biologic products targeting a novel pro-inflammatory cytokine to treat severe inflammatory diseases.

MedImmune and CTI will collaborate on the research and development of antibodies and other drug products targeting the High Mobility Group Box Chromosomal Protein 1 (HMGB-1), which is believed to be involved in the tissue damage associated with a range of inflammatory illnesses, such as rheumatoid arthritis and sepsis. The companies plan to focus on developing drug products with the potential to block HMGB-1, which if successful, could help reduce the injury and death associ-ated with severe inflammatory diseases and infections.

"CTI's proprietary anti-HMGB-1 technology is a great fit with our core expertise in antibody technology and anti-arthritic/anti-inflammatory disease research," commented James F. Young, Ph.D., MedImmune's president of research and development. "Elevated levels of HMGB-1 are found in many acute and chronic diseases, including rheumatoid arthritis, inflammatory bowel disease, hemorrhagic shock, sepsis, endotoxemia, and acute lung injuries. We believe that treat-ment with anti-HMGB-1 antibodies or antagonists may help alleviate or prevent the severe tissue damage that often results from such afflictions."

HMGB-1 is a cytokine, which means it is one of the many hormone-like proteins secreted by dif-ferent cell types that regulate the intensity and duration of an immune response. HMGB-1 is ex-pressed at high levels beginning approximately 12 to 72 hours after an inflammatory reaction of the immune system has been initiated and at about the time tissue damage is believed to occur. Because of the timing and the duration of its expression, HMGB-1 could potentially be a more important factor than other cytok

Contact: Scott Solomon
Sharon Merrill Associates, Inc.

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