e, linking cellular structure, protein expression and function, said Walter Schubert, M.D., Founder and Chief Executive Officer of MelTec. Our system has the potential to become a key technology that paves the way for a more systematic approach to understanding disease pathology and treatment, by looking at how protein networks in cells determine cellular function. We believe that the NCDS can enable researchers to simultaneously identify and prioritize drug targets and lead compounds directly from tissue samples of patients, and may help with diagnosis as well.
It is known that lymphocytes, because of their innate ability to invade and progressively destroy cells, play an essential role in cellular immune response, autoimmune diseases and transplant rejection. They work by either migrating as single cells, or acting in unison forming dense lymphoid tissue. For example, lymphocyte invasion of the artery wall is an early event in the pathogenesis of arteriosclerosis.
According to the study, the NCDS is capable of detecting and monitoring at least 85% of the cells involved in tissue migration and the protein networks that participate in the involved mechanisms. This newly available data is considered crucial for a better understanding of diseases linked with cellular migration, such as arteriosclerosis and cancer.
According to MelTec, the key to understanding the mechanisms underlying disease processes lies in deciphering the variations and interactions in the protein networks involved in specific disease pathways.
Currently, most of the relationships between the cellular environment and intracellular distribution of proteins are not well understood. With the NCDS technology a researcher can simultaneously discover the molecular phenotype of cells and the precise position of protein networks, thus enabling closer investigation of the hidden relationships between the structure, molecular expression and function of proteins.
MelTec GmPage: 1 2 3 Related biology news :1
Contact: Melissa Wainberg
. MelTec GmbH characterizes protein networks involved in T-cell invasion2
. Secretary of Energy announces seven E.O. Lawrence Award Winners3
. Popular Science announces Third Annual Brilliant 104
. The American Phytopathological Society announces 2004 awards5
. NSF announces six FIBR awards to tackle some of biologys most challenging questions6
. Protemix corporation announces discovery of way to repair hearts damaged by diabetes7
. JGI announces community sequencing program portfolio8
. APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics9
. National Corn Growers Association announces valuable maize genome data now available to scientists10
. DFG announces three percent budget increase11
. Chemical Society announces EPA awards for environmentally friendly technology