It is known that lymphocytes, because of their innate ability to invade and progressively destroy cells, play an essential role in cellular immune response, autoimmune diseases and transplant rejection. They work by either migrating as single cells, or acting in unison forming dense lymphoid tissue. For example, lymphocyte invasion of the artery wall is an early event in the pathogenesis of arteriosclerosis.
According to the study, the NCDS is capable of detecting and monitoring at least 85% of the cells involved in tissue migration and the protein networks that participate in the involved mechanisms. This newly available data is considered crucial for a better understanding of diseases linked with cellular migration, such as arteriosclerosis and cancer.
According to MelTec, the key to understanding the mechanisms underlying disease processes lies in deciphering the variations and interactions in the protein networks involved in specific disease pathways.
Currently, most of the relationships between the cellular environment and intracellular distribution of proteins are not well understood. With the NCDS technology a researcher can simultaneously discover the molecular phenotype of cells and the precise position of protein networks, thus enabling closer investigation of the hidden relationships between the structure, molecular expression and function of proteins.
MelTec Gm
'"/>
Contact: Melissa Wainberg
m.wainberg@noonanrusso.com
212-696-4455 x220
Noonan/Russo Communications
3-Jul-2001