Melatonin: More Than You Bargain For?

Study Suggests Supplement Has Potential To Cause Unwanted Reactions In The Body

People who take the popular supplement melatonin hoping for antioxidant or sleep benefits may be getting more than they bargain for, according to Louisiana State University chemists. Their newly released findings show melatonin reacts with chemicals in the body to form compounds that could alter behavior.

Details about the research will appear in the peer-reviewed journal Chemical Research in Toxicology, published by the American Chemical Society (ACS), the world's largest scientific society. The paper will become available on the ACS Web May 26 and is tentatively scheduled to be in the journal's June 14 print edition.

Melatonin is produced naturally by the body to control sleep cycles, but is needed in only very low concentrations. It is sold as a sleeping aid and as an antioxidant. However, chemists William A. Pryor and Giuseppe L. Squadrito of the university's Biodynamics Institute say that the antioxidant properties of melatonin are very modest at best and that metabolizing excess melatonin may cause more harm than good. "It is our hypothesis," says Squadrito, "that secondary products of melatonin have as yet unrecognized health effects."

The scientists found that carbonate and nitrogen dioxide radicals, which are constantly formed in the human body from peroxynitrite, react with melatonin to form two cyclic metabolites that resemble brain signaling chemicals but whose biological function is unknown. "Our kinetic modeling, using competitive reactions, indicate that the reaction of melatonin with peroxynitrite-derived free radicals is physiologically important," states Squadrito adding that it "becomes even more important when taking melatonin as a supplement."

While admitting that it is unclear how increased amounts of the neurotransmitter-like metabolites impact health, Squadrito theorizes that "they could have an important effect on aspec

Contact: Charmayne Marsh
American Chemical Society

Page: 1 2

Related biology news :

1. Researcher Gains 30,000% Saving Using "Bargain Basement" Chemistry To Create Complex Industrially Useful Molecules

Post Your Comments:

(Date:6/23/2020)... FREDERICK, Md. (PRWEB) , ... ... ... a leading provider of gene-to-protein and monoclonal antibody development services, today announced ... of protein-based products and services to the pharmaceutical, diagnostics, and research industries. ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around for a ... of mass spectrometry in this field has gained a lot of momentum in the ... approach to use (LBA or MS)?” In many cases, either technology can answer ...
(Date:6/23/2020)... ... June 23, 2020 , ... In its June 22 online post, business and ... L. Sherley, M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex ... 16 that starting July 5 it would begin offering free tissue stem ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... ... The Indoor Lab, a leading provider of sensor solutions for monitoring foot ... ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology using Artificial Intelligence ... a health performance index system that scores all aspects of compliance similar to the ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry Association ... strong opposition to the recently introduced bicameral Facial Recognition and Biometric Technology ... federal use of nearly all biometric and related image analytics technologies, incorrectly labeling ...
(Date:6/23/2020)... ... 22, 2020 , ... Regen Suppliers, the one stop shop ... three, get the fourth unit free with no limit on the amniotic derived ... exosomes, have been a game changer for regenerative therapies. The products are manufactured ...
(Date:6/19/2020)... (PRWEB) , ... June 18, 2020 , ... The ... Its goal is to join forces to radically prolong life and find a way ... the aging period. This project was supported by various scientists from all over the ...
Breaking Biology Technology:
Cached News: