HOME >> BIOLOGY >> NEWS
Memorial Sloan-Kettering Investigators

New York, N.Y., January 23, 1998 - Memorial Sloan-Kettering Cancer Center (MSKCC) researchers delving into the fundamental mechanisms underlying one form of leukemia have learned how to interfere with the genetic changes that lead to this potentially fatal type of cancer. In laboratory studies, the investigators identified a combination of drugs that turn on proteins called transcription factors, which may be turned off in leukemia. The drug duo induces leukemia cells to mature and behave like normal, healthy blood cells. This finding, the first evidence supporting a new approach called "transcription therapy," may have broad implications for improving the treatment of other types of cancer that arise as a result of faulty gene transcription. The study was published in the February 1998 issue of the scientific journal Nature Genetics.

"This is exciting because we are taking our knowledge of how genes are regulated and using it to design an effective, targeted approach to treating cancer," said Dr. Pier Paolo Pandolfi, the geneticist who led the study. "We were able to show that this treatment was effective in mice, and we are planning to evaluate it soon in patients."

Specifically, Dr. Pandolfi and his team studied the molecular genetics underlying acute promyelocytic leukemia (APL), a type of leukemia that afflicts 2,000 to 3,000 Americans each year and has an especially abrupt onset. Five years ago, MSKCC investigators led by Dr. Raymond P. Warrell, Jr. showed that a drug called retinoic acid (RA) could be used to treat many patients with APL by inducing their cancer cells to mature, or differentiate, into healthy white blood cells. Differentiation therapy is an especially intriguing treatment approach, since it doesn't kill cells, but rather prompts them to "grow up" and behave normally.

Yet some APL patients remain resistant to RA treatment. Scientists looking at w
'"/>

Contact: Kelli Stauning
stauningk@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
26-Jan-1998


Page: 1 2 3 4

Related biology news :

1. Veterinary Memorial Fund transforms grief into promise
2. Andres Vazquez-Torres honored with 2004 Merck Irving S. Sigal Memorial Award
3. American Society for Microbiology honors Timothy Yahr with 2004 Merck Irving S. Sigal Memorial Award
4. Childrens Memorial, TGen announce partnership
5. Webcast of NSF Director Rita Colwells Chafee Memorial Lecture
6. Director of Emory Vaccine Center to give Wistar Institutes 1999 Tadeusz J. Wiktor Memorial lecture
7. Snapshot of new drug marks a major advance by Memorial Sloan-Kettering researchers
8. Chern Memorial Award Presented To Wistar Institute Postdoctoral Fellow
9. APS announces four 2004 Young Investigators awards
10. EMBO Young Investigators 2000 2002
11. Investigators use guilt-by-association strategy to track potential cancer causing genes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... ... Hosted at the Las Vegas Convention Center, and brought to you by ... of MJBiz business professionals in the world. With over 1,300 exhibitors from more than ... show quite like it. Atlantic Ultraviolet will exhibit at Booth C9217, showcasing its ...
(Date:11/12/2019)... MEMPHIS, Tenn. (PRWEB) , ... November 12, 2019 ... ... in contract manufacturing of orthopedic medical devices, today announced the creation of a ... The reality in the Medical Device industry is that the regulatory element to ...
(Date:11/12/2019)... ... November 12, 2019 , ... The Arnold and ... universities and research institutions for its Instrumentation Grant for Advanced Light-Sheet Microscopy ... million per site for the acquisition of instrumentation, development and maintenance; support for ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... (PRWEB) , ... November 05, 2019 , ... ... technology, announced it has received CE Mark for its Fusion Bx 2.0 prostate ... arm and user-friendly interface, the Fusion Bx 2.0 will give urologists across Europe ...
(Date:11/2/2019)... ... October 31, 2019 , ... drug360 graph, a breakthrough knowledge ... drug360 brings tellic’s expertise in biomedical language processing and machine learning to bear ... between genes, diseases, variants, phenotypes, and other biomedical entities. Researchers and analysts ...
(Date:10/29/2019)... ... October 29, 2019 , ... Modality ... Silver sponsorship and cold chain validation workshop at the Biomanufacturing World Summit (BMWS19) ... Diego, California. , The Biomanufacturing World Summit brings together pharmaceutical executives, ...
(Date:10/22/2019)... ... , ... Catalent, a global leader in clinical supply services, today announced that ... in a panel session titled “Cell and Gene Therapy Logistics” at the upcoming Health ... on Oct. 28-30, 2019. , The panel session, on Wednesday, Oct. 30 at 8:30 ...
Breaking Biology Technology:
Cached News: