HOME >> BIOLOGY >> NEWS
Method to visualize gene activity may provide insight into normal development & genome function

A technique developed by University of California, San Diego biologists, which uses bright fluorescent dyes to reveal the activity of genes in individual cells of an organism, promises to be a boon to developmental biologists, and may provide new insight into how cancerous tumors begin and grow.

The advance, described in the August 6 issue of Science, allows researchers, for the first time, to simultaneously visualize the activity of multiple genes in the same cell. The combination of genes that are active in a particular cell during development determines that cell's fate--what type of cell it becomes. The advance also makes it possible to quantify how active a gene is, and even infer the genetic makeup of an organism.

"In addition to facilitating our own research on fruit fly development, there are many potential applications for this technique," says Ethan Bier, a professor of biology at UCSD who led the research team. "For example, it could be used to understand how tumors arise and grow, by revealing what genes are turned on and when. With this information, it should be possible for cancer biologists to predict how aggressive a tumor will be from its early patterns of gene expression."

"Cell fate decisions must be understood in order for any of the incredible medical potential of stem cell therapy to be realized," adds Dave Kosman, a research scientist in the Bier and McGinnis laboratories and lead author on the paper

Multiplex labeling, as the technique is called, uses RNA tagged with a fluorescent molecule to signal that a gene is turned on. When a gene is "on" it produces RNA copies--gene transcripts--of itself. The biologists designed fluorescently-tagged RNA molecules that are complementary to the gene transcripts, and bind to them like Velcro. Therefore a fluorescent beacon reveals the existence and location of the RNA gene copy.

"Multiplex labeling has allowed us to directly m
'"/>

Contact: Sherry Seethaler
sseethaler@ucsd.edu
858-534-4656
University of California - San Diego
5-Aug-2004


Page: 1 2 3

Related biology news :

1. Method produces uniform, self-assembled nanocells
2. Newer methods added, scope expanded in new Methods of Soil Analysis Book
3. Method quickly surveys yeast genome by gene function, not sequence
4. Scientists identify key risk factor for canine arthritis: Method may eventually give humans similar warning
5. Researchers Track Path Of Safer Gene Delivery Method
6. New Cell Isolation Method Will Aid In Studying Tumor Development
7. Scientists Devise Method To Address Conflict Between Molecular Clock, Fossil Record Of Mammalian Evolution
8. New Method For Destroying Potentially Deadly Toxins In Drinking Water
9. Method May Be Key In Combating Diarrhea In Animals And Children
10. Microbiologist Develops Method For Dyeing Fabrics With Gold
11. Subterranean Mapping Method Will Find Homes For Pollution-Eating Bacteria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2019)... ... July 10, 2019 , ... Inference Solutions ... service organizations, today announced its role in Pizza Hut Australia’s digital transformation ... its franchisees. A key part of this initiative is implementation of an automated ...
(Date:7/9/2019)... ... July 08, 2019 , ... ... of Danisco’s ownership of the innovation behind two Danisco amylase patent applications (EP2859097 ... could be based on prior art was without merit and awarded costs to ...
(Date:6/25/2019)... ... June 25, 2019 , ... ActX has launched ... easily available from 23andMe, customers can get access to professionally reviewed genetic screening ... both 23andMe Ancestry and Health + Ancestry customers., With the ActX + 23andMe ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are the magic bullet ... products rely on these ingredients to create stable quality food that can withstand ... shift triggers food formulators to seek out alternatives for starches, gums and chemical ...
(Date:5/8/2019)... ... ... hands, Atlas is on the large side for a Quarter Horse. He and his ... When loping around a corner in late 2017, Atlas tripped and partially tore his ... able to walk. Fortunately Atlas’ owner, Kelly, sought the opinion of her veterinarian, Dr. ...
(Date:5/4/2019)... ... May 03, 2019 , ... ... the Diopsys® ffERG/Photopic Negative Response vision test, a new full field ... it is estimated that 6.3 million Americans will have glaucoma, with black Americans ...
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading experts ... so be sure to register today to save your place! Participate in the discussion ... upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials – The ...
Breaking Biology Technology:
Cached News: