HOME >> BIOLOGY >> NEWS
Mice Lacking Gene Show Reduced Alcohol Preference And Sensitivity

l. To make sure the mice were not simply avoiding the taste of alcohol, they were later given a choice between water and a saccharine (sweet) or quinine (bitter) solution. The location of the bottles was also switched, to assure that the mice were not going repeatedly to one bottle simply out of habit. The mice lacking the D2 receptor shied away from the alcohol, while the normal mice showed a preference for it. There were no differences between the normal mice and mice lacking D2 receptors in their consumption of saccharine or quinine. The mice missing the D2 gene did show a lower sensitivity to alcohol, meaning they demonstrated less disturbance in balance and activity at identical blood alcohol levels.

The D2 receptor has been the subject of intense scrutiny. Some researchers have proposed that mutations in the D2 receptor gene in humans are one of the roots of alcoholism. The OHSU and VA research paints a more complex picture. "It says that the D2 receptor is in some way involved in the animal's choice to drink or not to drink," said David Grandy, Ph.D., associate professor of physiology and pharmacology at OHSU and a co-author of the paper. "But how the receptor relates to euphoria or abuse of the drug isn't yet clear. It will require extensive genetic screening of humans to determine which specific mutations in the D2 receptor gene may be connected with alcoholism. Our research doesn't point towards a single 'alcoholic' gene, but rather towards a complex interaction between several receptors and systems in the brain."

Further research will focus on measuring those interactions. Phillips and other OHSU and VA scientists have also found that mice without a receptor sensitive to serotonin, another substance connected with pleasure, drink more than mice that have the gene. Phillips, Grandy and others are now working on breeding mice that lack both the D2 and serotonin receptors.


'"/>

Contact: Henry Sessions
sessionh@ohsu.edu
503-494-8231
Oregon Health & Science University
20-Oct-1998


Page: 1 2 3

Related biology news :

1. UCSF/Gladstone Finding May Explain HIVS Ability To Infect Cells Lacking The Key Target Of HIV: The CD4 Receptor
2. Mice Lacking The Pax8 Gene Suffer From Hypothyroidism And Fail To FormThyroxin-Producing Cells Of The Thyroid Gland
3. OHSU Scientists Discover Mice Lacking Dopamine Receptor Are Supersensitive To Alcohol, Cocaine And Methamphetamine
4. Reduced daily eye patching effectively treats lazy eye
5. Reduced-calorie diet adds nearly two years to dogs life span
6. Vions TAPET Organisms Demonstrate Reduced Virulence, Increased Safety While Retaining Ability To Specifically Target Tumors
7. Marylands Death Rate For Pancreatic Cancer Surgery Reduced By Medical Regionalization
8. Reduced Nutrients Still Cause Problems In The Neuse And Tar-Pamlico Rivers
9. Low Cholesterol? Reduced Sodium? What Do These Terms Really Mean?
10. Alcohol-use and depression among pregnant and postpartum women
11. Alcoholism risk linked to gene involved in brain chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2017)... DUBLIN , Feb 10, 2017 ... PharmaBiotech,s new report "Personalized Medicine - Scientific and Commercial ... ... in personalized medicine. Diagnosis is integrated with therapy for selection ... emphasis on early detection and prevention of disease in modern ...
(Date:2/8/2017)... Feb. 7, 2017 The biometrics market ... the confluence of organizations, desires to better authenticate ... systems (password and challenge questions), biometrics is quickly ... systems. The market is driven by use cases, ... consumer and enterprise uses cases, with consumer-facing use ...
(Date:2/6/2017)... 2017 According to Acuity Market Intelligence, ... authorities to continue to embrace biometric and digital ... Automated Border Control (ABC) eGates and 1436 Automated ... than 163 ports of entry across the globe. ... a combined CAGR of 37%. APC Kiosks reached ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... Financial Highlights (in ... Months Ended December 31,Twelve Months Ended December 31,20162015% ... $           300$     ... Revenue 3539(10)%9498(4)%Kuvan Net Product Revenue ... 756025%297303(2)%Vimizim Net Product Revenue ...
(Date:2/23/2017)... 23, 2017 /PRNewswire/ - The Fight Against Cancer Innovation ... (OICR) are pleased to report that Fusion Pharmaceuticals Inc. ... Johnson & Johnson Innovation – JJDC, Inc. (JJDC) as ... HealthCap, TPG Biotechnology Partners, and Genesys Capital, as well ... ...
(Date:2/23/2017)... -- In Atlanta, it seems everyone has a chance to express ... an expressive and dynamic community unlike any other. The businesses ... it. With their newest salon in ... carry on that tradition with a unique, fresh approach to ... is the newest of 13 nationwide locations, each of them ...
(Date:2/23/2017)... , Feb. 23, 2017  Imanis Life ... product line of oncolytic vaccinia viruses for virotherapy ... as part of Genelux,s proprietary, vaccinia virus-based technology ... excited to enter into a partnership with Genelux ... oncolytic vaccinia viruses for use in research," said ...
Breaking Biology Technology:
Cached News: