HOME >> BIOLOGY >> NEWS
Mice become first animals to produce other species' sperm

PHILADELPHIA -- With pinhead-sized grafts of testicular tissue from newborn mammals, scientists at the University of Pennsylvania have induced mice to produce fully functional sperm from evolutionarily distant species. The result has important implications for preserving the germ lines of critically endangered species as well as prized livestock.

The study, in which male mice produced functional gametes first from other mice and then from pigs and goats, is reported in the Aug. 15 issue of the journal Nature.

"This is the first report of complete spermatogenesis from tissue grafted across species," said Ina Dobrinski, assistant professor of large animal reproduction in Penn's School of Veterinary Medicine. "The production of functionally competent sperm from three different mammals indicates that testis tissue grafting may be applicable to a wide variety of species."

The work also yielded the first functional sperm from immature reproductive tissue, meaning sperm could be derived even from individuals that have not reached sexual maturity. Unlike cryonic approaches to preservation, testis tissue grafting offers a potentially inexhaustible supply of male gametes.

Mice with the testis grafts could aid studies of the effects of drugs -- including potential male contraceptives -- on sperm production. The mice also give scientists a valuable model to better understand testicular function, many aspects of which remain murky.

Dobrinski and colleagues grafted as much as one cubic millimeter of tissue from the testes of newborn mice, goats and pigs onto the backs of mice. As many as eight miniature testes developed, and in vitro fertilization revealed that the sperm produced by those testis grafts were functional.

"At least 60 percent of grafts grew into functional testis tissue under the skin," Dobrinski said, "and those grafts produced as much sperm, gram for gram, as testes in the donor species. Some grafts grew more
'"/>

Contact: Steve Bradt
bradt@pobox.upenn.edu
215-573-6604
University of Pennsylvania
14-Aug-2002


Page: 1 2

Related biology news :

1. $18 million bioinformatics center to become weapon against deadly diseases
2. Biochemist becomes 15th UT Southwestern faculty member serving on National Academy of Sciences
3. Brain cells become more discriminating when they work together
4. How meals become bones
5. Adult mouse bone marrow stem cells can become cells of the nervous system
6. Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
7. Another global warming surprise: Grasslands may become wetter as temperatures rise
8. Indiana University to become NASA base for space biology studies
9. UNC HIV-AIDS screening, prevention method could become national model for cutting illness
10. Clock tells time at such speed that reading it becomes challenge
11. Jefferson scientists show neural stem cells can become dopamine-making brain cells in laboratory

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... ... treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan ... Drug Discovery. , Dr. Canan previously served as Executive Director of Global Health ...
(Date:8/26/2020)... ... August 25, 2020 , ... Catalent, the leading global ... and gene therapies, and consumer health products, today announced that two Catalent Biologics ... Expo, taking place between Aug. 31 – September 4, 2020. , On Wednesday, ...
(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. ... the X-ray analysis community, presenting current news and crystallographic research. , The ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... 2020 , ... Medial EarlySign , a leader in ... high-burden diseases, and Centric Consulting, a business and technology consulting firm, today announced ... in order to identify and prioritize patients for care. , Combining Centric’s management ...
(Date:7/10/2020)... KONG (PRWEB) , ... July 09, 2020 , ... ... compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish ... the PolyU research team led by Dr MA has been using the zebrafish ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... growth of 40% in 2020, despite many obstacles created as a result of ... increase revenue for its partnered medical practices and medical manufacturers by expanding access ...
Breaking Biology Technology:
Cached News: