HOME >> BIOLOGY >> NEWS
Mice provide insight into bone metabolism disorders

St. Louis, August 4, 2002 -- Mice lacking a protein called SHIP (Src homology 2-containing inositol-5-phosphatase) have twice as many cells that breakdown bone as normal mice, according to a study led by Washington University School of Medicine in St. Louis. Consequently, the mice lose a significant amount of bone density and thickness. These results not only provide insight into diseases of bone metabolism such as osteoporosis, but the mouse strain used in the study also may be the first animal model of a rare genetic disease called juvenile Paget's disease (JPD).

"Our findings are important for understanding how bone forms and breaks down, and how those processes are disrupted in diseases like JPD," says F. Patrick Ross, Ph.D., research professor of pathology and immunology at the School of Medicine.

Ross led the study, which appears online in Nature Medicine on Aug. 5 and will be published in the September issue of the journal. The first authors were Sunao Takeshita, Ph.D., and Noriyuki Namba, Ph.D., both post-doctoral fellows in Ross' laboratory.

JPD, also known as hereditary hyperphosphatasia or hyperostosis corticalis deformans juvenilis, is a painful skeletal disease characterized by abnormally fast formation and breakdown of bone throughout the body that leads to debilitating fractures and deformities beginning soon after birth.

In healthy individuals, there is a careful balance between the number of osteoblasts (cells that create bone) and osteoclasts (cells that break down bone). But research suggests that people with JPD have more osteoclasts and that these cells are larger than normal, which creates a dangerous imbalance in bone turnover.

Researchers in Vancouver recently engineered a strain of mice lacking the gene for SHIP. The mice have abnormally high numbers of macrophages, a type of immune cell. Because macrophages can develop into osteoclasts, the Washington University team hypothesized that the mice lack
'"/>

Contact: Gila Z. Reckess
reckessg@msnotes.wustl.edu
314-286-0109
Washington University School of Medicine
4-Aug-2002


Page: 1 2

Related biology news :

1. Picking prostanoids to provide protection
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Essential smell gene may provide key to new insect repellents
5. Clemson University spin-off uses corn to make plastics, provide cleaner air
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. New discovery could provide tool to detect whether a cancer will develop and spread
9. Protective mechanism exploited by tumors may provide new cancer treatment
10. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
11. Fat cells could provide the key to a longer life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/27/2017)... 2017   Strategic Cyber Ventures , the industry,s ... a $3.5 million investment in  Polarity , the first ... is DC based and is led by cybersecurity veterans ... Ron Gula , also a longtime cybersecurity veteran ... this series A round of funding. This new funding ...
(Date:2/21/2017)... -- Der weltweite Biobanking-Sektor wird bis zum ... mit mehr als 50 Vertretern aus verschiedenen Branchen wurde aber ... diese Prognose zu realisieren. ... Zu den Schwierigkeiten für ... für die Biobank, die Implementierung Zeit sparender Technologien, ein ...
(Date:2/10/2017)... DUBLIN , Feb 10, 2017 ... PharmaBiotech,s new report "Personalized Medicine - Scientific and Commercial ... ... in personalized medicine. Diagnosis is integrated with therapy for selection ... emphasis on early detection and prevention of disease in modern ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... ... March 23, 2017 , ... Advanced Polymer ... hire of Dr. Sigmund “Sig” Floyd as Vice President ? Global Business Development. ... development activities. , “Dr. Floyd’s career has spanned 30 years in the chemicals ...
(Date:3/22/2017)... CAMBRIDGE, Mass. , March 22, 2017 ... announced that it has eclipsed the 130 million covered ... Cross Blue Shield of Texas . ... stages, the Company continues to enjoy strong payor acceptance ... of its clinical programs and genetic counseling, its industry-leading ...
(Date:3/22/2017)... /PRNewswire/ - FACIT announced a seed stage investment ... start-up created by FACIT focused on developing a ... with non-dilutive capital, achieves a targeted $3.0M financing ... Propellon to accelerate the nomination of a candidate ... entering a strategic partnership for clinical trials in ...
(Date:3/22/2017)... Ca (PRWEB) , ... March 21, 2017 , ... ... clearance of biologics. To acquire information on the desired increase and/or decrease in ... biopharmaceutical industry for rapid N-glycosylation profiling of therapeutic antibodies. , To meet ...
Breaking Biology Technology:
Cached News: