Mice provide insight into bone metabolism disorders

St. Louis, August 4, 2002 -- Mice lacking a protein called SHIP (Src homology 2-containing inositol-5-phosphatase) have twice as many cells that breakdown bone as normal mice, according to a study led by Washington University School of Medicine in St. Louis. Consequently, the mice lose a significant amount of bone density and thickness. These results not only provide insight into diseases of bone metabolism such as osteoporosis, but the mouse strain used in the study also may be the first animal model of a rare genetic disease called juvenile Paget's disease (JPD).

"Our findings are important for understanding how bone forms and breaks down, and how those processes are disrupted in diseases like JPD," says F. Patrick Ross, Ph.D., research professor of pathology and immunology at the School of Medicine.

Ross led the study, which appears online in Nature Medicine on Aug. 5 and will be published in the September issue of the journal. The first authors were Sunao Takeshita, Ph.D., and Noriyuki Namba, Ph.D., both post-doctoral fellows in Ross' laboratory.

JPD, also known as hereditary hyperphosphatasia or hyperostosis corticalis deformans juvenilis, is a painful skeletal disease characterized by abnormally fast formation and breakdown of bone throughout the body that leads to debilitating fractures and deformities beginning soon after birth.

In healthy individuals, there is a careful balance between the number of osteoblasts (cells that create bone) and osteoclasts (cells that break down bone). But research suggests that people with JPD have more osteoclasts and that these cells are larger than normal, which creates a dangerous imbalance in bone turnover.

Researchers in Vancouver recently engineered a strain of mice lacking the gene for SHIP. The mice have abnormally high numbers of macrophages, a type of immune cell. Because macrophages can develop into osteoclasts, the Washington University team hypothesized that the mice lack

Contact: Gila Z. Reckess
Washington University School of Medicine

Page: 1 2

Related biology news :

1. Picking prostanoids to provide protection
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Essential smell gene may provide key to new insect repellents
5. Clemson University spin-off uses corn to make plastics, provide cleaner air
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. New discovery could provide tool to detect whether a cancer will develop and spread
9. Protective mechanism exploited by tumors may provide new cancer treatment
10. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
11. Fat cells could provide the key to a longer life

Post Your Comments:

(Date:11/12/2015)... -- A golden retriever that stayed healthy despite having the ... a new lead for treating this muscle-wasting disorder, report ... MIT and Harvard and the University of São Paolo ... Cell, pinpoints a protective gene that boosts muscle ... Boston Children,s lab of Lou Kunkel , PhD, ...
(Date:11/11/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology company ... to announce that it will be a Sponsor of the ... be held November 17-19 in Hamburg , ... iMedNet , MedNet,s easy-to-use, proven and affordable ... been able to deliver time and cost savings of up ...
(Date:11/9/2015)... , Nov. 09, 2015 ... the addition of the "Global Law ... their offering. --> http://www.researchandmarkets.com/research/52ggmn/global_law ) ... "Global Law Enforcement Biometrics Market 2015-2019" ... Research and Markets ( http://www.researchandmarkets.com/research/52ggmn/global_law ) has ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an essential micronutrient ... to proteins, copper is also toxic to cells. With a $1.3 million award ... will conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. ...
(Date:11/24/2015)... Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... on behalf of the Toronto Stock Exchange, confirms that ... are no corporate developments that would cause the recent ... --> --> About Aeterna Zentaris Inc. ... --> Aeterna Zentaris is a specialty biopharmaceutical ...
(Date:11/24/2015)... , November 24, 2015 ... market research report "Oligonucleotide Synthesis Market by Product & ... Gene Synthesis, Diagnostic, DNA, RNAi), End-User (Research, Pharmaceutical & ... by MarketsandMarkets, the market is expected to reach USD ... 2015, at a CAGR of 10.1% during the forecast ...
(Date:11/24/2015)... ... ... The Academy of Model Aeronautics (AMA), led by its Executive Council, has ... Prix, to represent the First–Person View (FPV) racing community. , FPV racing has exploded ... of racing and several new model aviation pilots have joined the community because of ...
Breaking Biology Technology:
Cached News: