HOME >> BIOLOGY >> NEWS
Mice provide insight into bone metabolism disorders

St. Louis, August 4, 2002 -- Mice lacking a protein called SHIP (Src homology 2-containing inositol-5-phosphatase) have twice as many cells that breakdown bone as normal mice, according to a study led by Washington University School of Medicine in St. Louis. Consequently, the mice lose a significant amount of bone density and thickness. These results not only provide insight into diseases of bone metabolism such as osteoporosis, but the mouse strain used in the study also may be the first animal model of a rare genetic disease called juvenile Paget's disease (JPD).

"Our findings are important for understanding how bone forms and breaks down, and how those processes are disrupted in diseases like JPD," says F. Patrick Ross, Ph.D., research professor of pathology and immunology at the School of Medicine.

Ross led the study, which appears online in Nature Medicine on Aug. 5 and will be published in the September issue of the journal. The first authors were Sunao Takeshita, Ph.D., and Noriyuki Namba, Ph.D., both post-doctoral fellows in Ross' laboratory.

JPD, also known as hereditary hyperphosphatasia or hyperostosis corticalis deformans juvenilis, is a painful skeletal disease characterized by abnormally fast formation and breakdown of bone throughout the body that leads to debilitating fractures and deformities beginning soon after birth.

In healthy individuals, there is a careful balance between the number of osteoblasts (cells that create bone) and osteoclasts (cells that break down bone). But research suggests that people with JPD have more osteoclasts and that these cells are larger than normal, which creates a dangerous imbalance in bone turnover.

Researchers in Vancouver recently engineered a strain of mice lacking the gene for SHIP. The mice have abnormally high numbers of macrophages, a type of immune cell. Because macrophages can develop into osteoclasts, the Washington University team hypothesized that the mice lack
'"/>

Contact: Gila Z. Reckess
reckessg@msnotes.wustl.edu
314-286-0109
Washington University School of Medicine
4-Aug-2002


Page: 1 2

Related biology news :

1. Picking prostanoids to provide protection
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Essential smell gene may provide key to new insect repellents
5. Clemson University spin-off uses corn to make plastics, provide cleaner air
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. New discovery could provide tool to detect whether a cancer will develop and spread
9. Protective mechanism exploited by tumors may provide new cancer treatment
10. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
11. Fat cells could provide the key to a longer life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/3/2017)... , Feb. 3, 2017 A new independent ... Strategy Partners, LLP (IdSP) . Designed to fill a ... complex identity market, founding partners Mark Crego ... combined years just in identity expertise that span federal ... non-profit leadership. The Crego-Kephart combined expertise has a common ...
(Date:2/2/2017)... -- Central to its deep commitment to honor the ... Prize Foundation today announced the laureates of the ... in their respective fields of Life Sciences and ... recognized with the 2017 Japan Prize for original ... the advancement of science and technology, but also ...
(Date:1/30/2017)... SAN FRANCISCO , Jan. 30, 2017   ... of the fastest growing genetic information companies, today announced ... 2016 financial results and provide 2017 guidance on Monday, ... a conference call that day at 4:45 p.m. Eastern ... call, Invitae,s management team will briefly review financial results, ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... (PRWEB) , ... February 21, 2017 , ... ... and biotech research and development (R&D), today announced the establishment of Genedata Limited ... Managing Director Kevin Teburi, a recognized expert in life science informatics. Creating the ...
(Date:2/21/2017)... ... 21, 2017 , ... Creation Technologies, a private company and ... manufacturers (OEMs) , today announced it has received the ‘Highest Overall Customer Rating’ ... its category of electronics manufacturing services (EMS) providers with annual revenues over $500 ...
(Date:2/21/2017)... 21, 2017   Invitae Corporation (NYSE: NVTA), ... announced that members of the company,s management team will ... Care Conference on Monday, March 6, 2017 at approximately ... Boston, Massachusetts . The ... by visiting the investors section of the company,s website ...
(Date:2/20/2017)... 20, 2017 This report analyzes the worldwide markets ... Types: Xylanase, Amylase, Cellulase, and Others. The report provides separate ... Japan , Europe , ... , and Rest of World. Read the ... forecasts are provided for the period 2015 through 2022. Also, ...
Breaking Biology Technology:
Cached News: