HOME >> BIOLOGY >> NEWS
Mice provide insight into bone metabolism disorders

St. Louis, August 4, 2002 -- Mice lacking a protein called SHIP (Src homology 2-containing inositol-5-phosphatase) have twice as many cells that breakdown bone as normal mice, according to a study led by Washington University School of Medicine in St. Louis. Consequently, the mice lose a significant amount of bone density and thickness. These results not only provide insight into diseases of bone metabolism such as osteoporosis, but the mouse strain used in the study also may be the first animal model of a rare genetic disease called juvenile Paget's disease (JPD).

"Our findings are important for understanding how bone forms and breaks down, and how those processes are disrupted in diseases like JPD," says F. Patrick Ross, Ph.D., research professor of pathology and immunology at the School of Medicine.

Ross led the study, which appears online in Nature Medicine on Aug. 5 and will be published in the September issue of the journal. The first authors were Sunao Takeshita, Ph.D., and Noriyuki Namba, Ph.D., both post-doctoral fellows in Ross' laboratory.

JPD, also known as hereditary hyperphosphatasia or hyperostosis corticalis deformans juvenilis, is a painful skeletal disease characterized by abnormally fast formation and breakdown of bone throughout the body that leads to debilitating fractures and deformities beginning soon after birth.

In healthy individuals, there is a careful balance between the number of osteoblasts (cells that create bone) and osteoclasts (cells that break down bone). But research suggests that people with JPD have more osteoclasts and that these cells are larger than normal, which creates a dangerous imbalance in bone turnover.

Researchers in Vancouver recently engineered a strain of mice lacking the gene for SHIP. The mice have abnormally high numbers of macrophages, a type of immune cell. Because macrophages can develop into osteoclasts, the Washington University team hypothesized that the mice lack
'"/>

Contact: Gila Z. Reckess
reckessg@msnotes.wustl.edu
314-286-0109
Washington University School of Medicine
4-Aug-2002


Page: 1 2

Related biology news :

1. Picking prostanoids to provide protection
2. Study by Israeli scientists provides insight on DNA code
3. Adaptive changes in the genome may provide insight into the genetics of complex disease
4. Essential smell gene may provide key to new insect repellents
5. Clemson University spin-off uses corn to make plastics, provide cleaner air
6. Method to visualize gene activity may provide insight into normal development & genome function
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. New discovery could provide tool to detect whether a cancer will develop and spread
9. Protective mechanism exploited by tumors may provide new cancer treatment
10. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
11. Fat cells could provide the key to a longer life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 15.1% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
(Date:3/22/2017)... , March 21, 2017 ... Cloud used by retailers such as 1-800-Flowers and ... platform — Product Recommendations and Replenishment. Using Optimove,s machine ... more personalized product and replenishment recommendations to their ... also on predictions of customer intent drawn from ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Pittcon is pleased to ... and scientific instruments. This year’s symposium, organized by the Pittcon 2018 program chair, ... Bioanalytical Applications.” This dynamic presentation will discuss novel ionization processes, high throughput IMS-MS ...
(Date:8/15/2017)... , ... August 15, 2017 , ... ... shopping cart. Now mobile responsive, the new website makes it easy to navigate ... in between. Users can now find detailed product information, educational industry content and ...
(Date:8/11/2017)... , ... August 11, 2017 , ... A staple in ... this month that will incorporate important key elements including a new digital marketing strategy ... that has supported them, Bill Miller has partnered with the South Texas Blood & ...
(Date:8/10/2017)... Linda, Ca (PRWEB) , ... August 09, 2017 ... ... exosomes for regenerative medicine applications in the clinic is here. The team at ... EVs present in conditioned medium for clinical studies. , Dr. Travis Antes, ...
Breaking Biology Technology:
Cached News: