HOME >> BIOLOGY >> NEWS
Mice show how to calm anxiety

March 29, 2000 -- Scientists have found a genetic switch that helps calm anxiety in "stressed out" mice.

In three articles published in the April 2000 issue of the journal Nature Genetics, three independent groups of researchers report that Crhr2 (corticotropin-releasing hormone receptor-2), which is found in pituitary gland tissue and in other areas of the brain, actually quells the stress response in mice.

One of the leaders of the research efforts, Michael G. Rosenfeld, an HHMI investigator at the University of California, San Diego (UCSD), cautioned that the discoveries represent only a beginning in understanding the complexities of the stress response.

"It has long been known that many severe psychiatric disturbances show a heightening of the anxiety response," Rosenfeld said. "With these findings, we provide an initial motivation for further dissecting two distinct receptor systems in terms of potential drug discovery programs."

Rosenfeld's research group included his former UCSD colleague Toshimitsu Kishimoto, who is now at Yoshitomi Pharmaceuticals in Japan, and Jelena Radulovic and Joachim Spiess at the Max Planck Institute for Experimental Medicine in Germany. The other groups were from the Oregon Health Sciences University and The Salk Institute.

When a human or animal is stressed, the hypothalamus secretes the hormone, corticotropin-releasing hormone (Crh), which stimulates the pituitary gland to release additional hormones. These hormones from the pituitary gland cause the adrenal gland to secrete hormones that stoke the stress response, increasing anxiety, energy and blood pressure, and suppressing immune responses.

According to Rosenfeld, previous studies by his group and by other researchers revealed the existence of two distinct receptors for Crh -- Crhr1 and Crhr2 -- in the pituitary and in other brain regions involved
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
29-Mar-2000


Page: 1 2 3

Related biology news :

1. Alcohol researchers relate a genetic factor to anxiety in women
2. Researchers discover anxiety and aggression gene in mice
3. The genetic basis for caffeine-induced anxiety discovered
4. Relaxed mice may provide clues for treating anxiety
5. The pathway to anxiety begins early in life
6. Stressed-out mice offer clues to depression, anxiety, anorexia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... , ... May 21, 2020 , ... ... across the North Shore and Greater Boston area, is pleased to announce a ... one of the busiest group practices in the area, Agility Orthopedics is focused ...
(Date:5/14/2020)... (PRWEB) , ... May 13, 2020 , ... ... launch of Bonlacta™, its latest enzyme for the lactose-free dairy market. This unique ... wide range of lactose-free dairy products at competitive costs across North America. , ...
(Date:5/6/2020)... LEXINGTON, Mass. (PRWEB) , ... May 06, 2020 , ... ... , a privately held medical technology company dedicated to improving the quality, safety, efficacy ... new partnership that will help SCDAA deliver on its mission and meet its goals. ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 14, 2020 , ... ... stem/stromal cell (hMSC) working cell banks and hMSC bioprocess systems, today announced ... multi-format collection of hMSC-derived extracellular vesicles (EVs). RoosterCollect™-EV-CC is the only system ...
(Date:5/15/2020)... (PRWEB) , ... May 14, 2020 , ... This new ... unforeseen and the most pressing questions answered quickly as the need arises. Lachman’s OnCall ... offering valuable advice at affordable rates. , Lachman OnCall™ SMEs are available normal ...
(Date:5/14/2020)... ... May 12, 2020 , ... DuPont Nutrition & Biosciences ... for all personal care ingredients in Russia and Belarus. Beginning May 1, Interdisp ... for personal care. , The GENENCARE®OSMS product line contains a range ...
(Date:5/14/2020)... ... May 13, 2020 , ... In collaboration with Sartorius, Biocompare ... the Life Science Lab . The comprehensive information source was created for life ... liquid handling to contamination control. , The content hub features the latest guidance ...
Breaking Biology Technology:
Cached News: