Mice with human protein, COX-2, exhibit age-related memory loss similar to Alzheimer...( roscience meeting shows that the area o...)

"In a stroke, a core part of the affected brain is destroyed, but there's a region around the core that isn't immediately destroyed, but is at high risk for damage," explains Andreasson. "If you can save that area, called the penumbra, or save a large part of it, that would have huge potential to improve recovery after stroke."

While studies looking at COX-2 inhibitors in patients with stroke haven't begun, scientists at Johns Hopkins have started a study of people at high risk of developing Alzheimer's disease to see if using COX-2 inhibitors can prevent or delay that disease. Since participants in the study don't have the disease, it will take many years for the researchers to know for sure if there is an effect.

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Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
14-Nov-2001