HOME >> BIOLOGY >> NEWS
MicroCAT A Welcome Sight To Geneticists And Mice

OAK RIDGE, Tenn., Sept. 22, 1998 -- Biologists studying genetic mutations and diseases will soon have a new ultra-high-resolution imaging tool to examine soft tissue and skeletal detail of mice and other laboratory animals -- without killing them.

The MicroCAT system, developed by researchers at the Department of Energy's (DOE) Oak Ridge National Laboratory (ORNL), generates three-dimensional images with 10 times the resolution of conventional imaging systems. With MicroCAT, researchers no longer will have to rely on visible genetic markers and physical examinations to discover the presence of mutations. And, because they don't have to dissect the mice, researchers will be able to study the development of a mutation over several weeks or months.

"This means we can survey many offspring of mutagenized mice for organ or skeletal abnormalities and for changes that occur as a mouse ages or is exposed to different environmental conditions -- and then still breed the mouse for genetic analysis," said Dabney Johnson, a genetics researcher in ORNL's Life Sciences Division.

MicroCAT arose from Johnson and colleagues, quest for a better screening tool to study genetic mutations in the world's largest research colony of 70,000 mice at ORNL. The lab's biologists needed a device to quickly and cost-effectively screen the mouse colony, which represent about 400 mutant strains. That's why Michael Paulus and others in ORNL's Instrumentation and Controls Division became involved.

This new device, Johnson believes, will allow ORNL to be among the leaders in the effort to analyze gene function and identify mouse models of human genetic diseases.

"The imaging technology and the kinds of image analysis and reconstruction software that the Paulus team is integrating are revolutionary," Johnson said. "And this is the kind of thing that national laboratories like ORNL can do best because they have diverse resources and expertise."

Paulus and a team that includes Shaun
'"/>

Contact: Ron Walli
wallira@ornl.gov
(423) 576-0226
DOE/Oak Ridge National Laboratory
22-Sep-1998


Page: 1 2 3

Related biology news :

1. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
2. Snakehead in your inbox? Welcome to the nonindigenous Aquatic Species Alert System
3. Sightless cavefish may offer clues to eye growth, Science authors report
4. Transgenic Mice With Widest Known Range Of Vision Among Mammals Created To Investigate Human Vision Problems, Evolution Of Sight
5. Geneticists show ripple effects of gene mutations
6. Geneticists trace sticky rices origins
7. Geneticists tell ostrich farmers the secrets of sex
8. USC Holds 2nd Annual Medical Genetics Symposium; Nations Leading Geneticists Discuss The Future Of Genomic Research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. Crystallography ... X-ray analysis community, presenting current news and crystallographic research. , The latest ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... and expo uniting life science, data science, informatics and IT leaders goes VIRTUAL ... this period of uncertainty and change, Bio-IT takes the leadership role of keeping ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently announced ... for public health agencies of all sizes. With a focus on tracking symptoms ... find appropriate health care, Mosio helps public health departments automate communications and provide ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... ... therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its ... the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as ...
(Date:7/7/2020)... ... 06, 2020 , ... Bio-IT World has announced the winners ... the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance ... highlighting outstanding examples of how technology innovations and strategic initiatives can be powerful ...
(Date:7/1/2020)... ... 29, 2020 , ... The Interlocal Purchasing System (TIPS), a ... recently named BioFit Engineered Products an Awarded Vendor. Awarded Vendor status ... cafeteria tables, book trucks and carts at discounted pricing without the delay and ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a ... Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with ... , A Safe Space™ enabled business will provide a health performance index system that ...
Breaking Biology Technology:
Cached News: