HOME >> BIOLOGY >> NEWS
MicroCAT A Welcome Sight To Geneticists And Mice

OAK RIDGE, Tenn., Sept. 22, 1998 -- Biologists studying genetic mutations and diseases will soon have a new ultra-high-resolution imaging tool to examine soft tissue and skeletal detail of mice and other laboratory animals -- without killing them.

The MicroCAT system, developed by researchers at the Department of Energy's (DOE) Oak Ridge National Laboratory (ORNL), generates three-dimensional images with 10 times the resolution of conventional imaging systems. With MicroCAT, researchers no longer will have to rely on visible genetic markers and physical examinations to discover the presence of mutations. And, because they don't have to dissect the mice, researchers will be able to study the development of a mutation over several weeks or months.

"This means we can survey many offspring of mutagenized mice for organ or skeletal abnormalities and for changes that occur as a mouse ages or is exposed to different environmental conditions -- and then still breed the mouse for genetic analysis," said Dabney Johnson, a genetics researcher in ORNL's Life Sciences Division.

MicroCAT arose from Johnson and colleagues, quest for a better screening tool to study genetic mutations in the world's largest research colony of 70,000 mice at ORNL. The lab's biologists needed a device to quickly and cost-effectively screen the mouse colony, which represent about 400 mutant strains. That's why Michael Paulus and others in ORNL's Instrumentation and Controls Division became involved.

This new device, Johnson believes, will allow ORNL to be among the leaders in the effort to analyze gene function and identify mouse models of human genetic diseases.

"The imaging technology and the kinds of image analysis and reconstruction software that the Paulus team is integrating are revolutionary," Johnson said. "And this is the kind of thing that national laboratories like ORNL can do best because they have diverse resources and expertise."

Paulus and a team that includes Shaun
'"/>

Contact: Ron Walli
wallira@ornl.gov
(423) 576-0226
DOE/Oak Ridge National Laboratory
22-Sep-1998


Page: 1 2 3

Related biology news :

1. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
2. Snakehead in your inbox? Welcome to the nonindigenous Aquatic Species Alert System
3. Sightless cavefish may offer clues to eye growth, Science authors report
4. Transgenic Mice With Widest Known Range Of Vision Among Mammals Created To Investigate Human Vision Problems, Evolution Of Sight
5. Geneticists show ripple effects of gene mutations
6. Geneticists trace sticky rices origins
7. Geneticists tell ostrich farmers the secrets of sex
8. USC Holds 2nd Annual Medical Genetics Symposium; Nations Leading Geneticists Discuss The Future Of Genomic Research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2019)... ... October 03, 2019 , ... Mount Sinai researchers have discovered ... down from one generation to the next. In a study published in Nature Structural ... of this enzyme, leading to cancers and other diseases. , “DNA polymerase delta serves ...
(Date:9/30/2019)... ... September 30, 2019 , ... Foresight Institute, a leading think ... technologies, announced the winners for the 2019 Foresight Institute Feynman Prizes. These are ... nanotechnology/molecular manufacturing. , Established in 1993 and named in honor of pioneer physicist ...
(Date:9/30/2019)... (PRWEB) , ... September 30, ... ... leading think tank, research, and public interest organization focused on molecular manufacturing ... Student Prize. , The Award recognizes the College graduate or undergraduate student ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... ... has completed training and site qualification for clinical trial sites and physician investigators. ... screening of potential clinical trial participants. , Clinical trial sites are currently located ...
(Date:9/22/2019)... ... 2019 , ... ZRT Laboratory is pleased to ... . BDNF plays a vital role in protecting existing neurons in the central ... in the brain involved in learning, memory, and higher thinking. Low serum levels ...
(Date:9/17/2019)... , ... September 17, 2019 , ... ... improve success in chronic diseases, announces today that the U.S. Patent and Trademark ... combinatorial genetic algorithm to rank drug class recommendations for hypertension treatment. , ...
(Date:9/17/2019)... ... 2019 , ... A new episode of Advancements with Ted ... local listings for more information on this program. , The show will explore ... Singapore dedicated to developing advanced diagnostic technologies for the masses. Viewers will learn ...
Breaking Biology Technology:
Cached News: