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MicroRNA targets: How big is the iceberg?

rdered such that those targets that they considered most likely to be real were at the top. This strategy correctly identified all previously validated targets from a large database, and puts them near the top of the ordered lists. Moreover, Cohen and colleagues selected six additional predicted targets and were able to experimentally validate all of them.

This not only more than doubles the size of the iceberg's tip, but the fact that Cohen and colleagues publish their full lists and invite other researchers to check whether their favorite genes are likely to be microRNA targets, also suggests that we will soon get a better sense of what's under the water.


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Contact: Barbara Cohen
bcohen@plos.org
415-624-1206
Public Library of Science
13-Oct-2003


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