HOME >> BIOLOGY >> NEWS
Mighty mice are less susceptible to muscular dystrophy gene's effects

The Johns Hopkins scientists who first discovered that knocking out a particular muscle gene results in "mighty mice" now report that it also softens the effects of a genetic mutation that causes muscular dystrophy.

The findings, scheduled for the December issue of the Annals of Neurology and currently online, build support for the idea that blocking the activity of that gene, known as myostatin, may one day help treat humans with degenerative muscle diseases.

Working with mice carrying the genetic mutation that causes Duchenne muscular dystrophy in humans, the scientists discovered that mice without the gene for myostatin had less physical damage to their muscles and were stronger than other mice with the Duchenne mutation.

"'Knocking out' the myostatin gene isn't possible for treating patients, but blocking the myostatin protein might be," says senior investigator Se-Jin Lee, M.D., Ph.D., professor of molecular biology and genetics at Johns Hopkins School of Medicine. "However, myostatin still needs to be studied in people to see if it has the same role in our muscles as it has in mice."

The researchers caution that, even if myostatin does limit muscle growth in people, blocking it would not cure muscular dystrophy or any other degenerative muscle condition because the underlying cause of disease would be unchanged.

"However, increasing muscle mass and strength by blocking myostatin could conceivably delay progression or improve quality of life," notes first author Kathryn Wagner, M.D., Ph.D., assistant professor of neurology at Hopkins.

The Hopkins team bred mice without the myostatin gene with mice carrying the genetic mutation that causes Duchenne muscular dystrophy in humans. Muscular dystrophy mice completely lacking myostatin were more muscular and stronger than those with myostatin at 3, 6 and 9 months of age, the researchers report. Perhaps most importantly, their muscle tissue appeared to be health
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
25-Nov-2002


Page: 1 2 3

Related biology news :

1. Mighty mouse gene works the same way in people
2. Mighty things from small beginnings
3. International Expert To Discuss Ramifications At Local Lecture...Tracking Contaminants In The Mighty Mississippi And Other Large Rivers Worldwide
4. Females may be more susceptible to overindulge sweet tooth cravings than males
5. New York City study shows newborns more susceptible to pollution than their mothers
6. Biofilm antibiotic resistance may be susceptible to genetic approach
7. High-producing dairy cows are not more susceptible to illness
8. Some people of African descent more susceptible to heart condition, Science study suggests
9. Women more susceptible to orthostatic hypotension
10. New screening method identifies areas susceptible to Selenium contamination in Western United States
11. Drug users, Native Americans susceptible to infectious diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... , ... May 20, 2020 , ... ... manufacturing solutions for drugs, biologics, cell and gene therapies, and consumer health products, ... Gene Therapy, will be presenting at the ISCT 2020 Paris Virtual conference, which ...
(Date:5/14/2020)... ... May 12, 2020 , ... ... platform that helps Life Science Manufacturers accurately and easily project contracted liabilities ... development of Gross-to-Net models by projecting discounts/rebates to Commercial and Government entities, ...
(Date:5/6/2020)... ... May 06, 2020 , ... Sickle Cell Disease Association ... technology company dedicated to improving the quality, safety, efficacy and cost of red blood ... SCDAA deliver on its mission and meet its goals. In 2020 Hemanext will collaborate ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 13, 2020 , ... ... or phenotypic readouts, providing little or no information on the drug’s mechanism of ... comprehensive characterization of compounds by measuring the activity of molecular pathways. This information ...
(Date:5/1/2020)... (PRWEB) , ... April 30, 2020 , ... ... were announced today, honoring the businesses, policies, projects, and concepts that are actively ... revolutionary bioprinter for living cells, which has taken out the top prize in ...
(Date:4/22/2020)... ... 21, 2020 , ... Ripple Science today announced new initiatives ... are working remotely and have paused patient visits, forcing teams to do more ... during this uncertain time by giving research teams free access to Ripple for ...
(Date:4/1/2020)... ... March 30, 2020 , ... A joint venture between mobile ... earlier this year to bring telehealth to various government agencies, has now focused ... officials are currently?awaiting an Emergency Use Authorization (EUA) waiver from the FDA?to?perform?AI?testing in ...
Breaking Biology Technology:
Cached News: