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Migraine mouse provides insight into neurobiology of devastating headaches

en FHM mutations, CSD, and activation of pain in the brain. According to coauthor Dr. Daniela Pietrobon, "Other studies have implicated CSD as a trigger for the pain associated with migraine. Drugs which reduce the activity of calcium channels in the migraine brain may make the brain more resistant to CSD and may thus be able to prevent migraine attacks." The FHM migraine mouse will provide a unique tool for future studies into the mechanisms of migraine as well as a promising model for testing new treatments aimed at preventing migraine by reducing hyperexcitability and preventing CSD.

Arn M.J.M. van den Maagdenberg, Daniela Pietrobon, Tommaso Pizzorusso, Simon Kaja, Ludo A.M. Broos, Tiziana Cesetti, Rob C.G. van de Ven, Angelita Tottene, Jos van der Kaa, Jaap J. Plomp, Rune R. Frants, and Michel D. Ferrari: "A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression"


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Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
3-Mar-2004


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