HOME >> BIOLOGY >> NEWS
Millennium and the Whitehead Institute identify novel protein important in fat absorption

Discovery of Potential Target for Improved Obesity Therapeutics Described in the Cover Article of Molecular Cell

Cambridge, Mass., September 24, 1999 -- Millennium Pharmaceuticals, Inc (Nasdaq: MLNM) and the Whitehead Institute for Biomedical Research today announced the discovery of a novel protein involved in fat absorption. Data relating to the identification and function of the protein appear in today's issue of the journal Molecular Cell. The protein, FATP4, plays a role in transporting fatty acid molecules from the intestine into the body. Inhibition of the protein's function may provide new approaches to treating obesity.

The data, described in a paper titled "Identification of the major intestinal fatty acid transport protein," were generated collaboratively by scientists at Millennium and in the laboratory of Dr. Harvey F. Lodish at the Whitehead. FATP4 is a member of a family of fatty acid transport proteins and is expressed at high levels in enterocytes, a cell-type found in the intestinal lining. The addition of human FATP4 to cells in which the protein is not normally expressed resulted in a large increase in the uptake of fatty acids. Inhibition of FATP4 with anti-sense oligonucleotides in a mouse enterocyte cell-culture model produced a proportional reduction in the uptake of these fatty acid molecules.

"The transport of fatty acids from the intestines into the body is a key step in the absorption and metabolism of dietary fat and its conversion to body fat," said Lou Tartaglia, Ph.D., senior director of metabolic disease at Millennium. "The identification of the intestinal fatty acid transport protein provides new insight into the molecular and biochemical pathways involved in the transport and utilization of dietary fat," added Tartaglia.

"Previously, our laboratory had identified a novel class of proteins called FATPs, which are associated with fatty acid transport proteins," said Dr. Harvey F. Lodish of t
'"/>

Contact: Sally McCraven, Millenium Pharmaceuticals
mccraven@mpi.com
617-577-3548
Noonan/Russo Communications
24-Sep-1999


Page: 1 2 3

Related biology news :

1. Millenniums LDP(PS)-341 inhibits growth and induces death of cancer cells, appears to overcome chemotherapy resistance
2. Millennium and Bayer industrializing drug discovery process through ongoing successful research alliance
3. Science and Technology at the Millennium: Retrospect or Prospect Focus of AAAS Science and Technology Colloquium, April 11-13 in Washington, DC
4. Millennium and Wyeth-Ayerst announce the discovery of key potassium ion channel modulating proteins
5. Millennium Clones Diet-Induced Obesity Gene
6. Whitehead press seminar 2001: new horizons in the post-genome world
7. Whitehead Institute receives National Science Foundation grant to sequence Neurospora
8. Whitehead press seminar: Beyond the scientific frontier
9. Whitehead Receives $35 Million Grant From National Human Genome Research Institute (NHGRI)
10. Whitehead Receives $7 million NIH Grant To Build High-Speed Sequencing Machines
11. Whitehead Study Supports Existence Of Ancient RNA World, Helps Provide Insight Into Early Evolution Of Life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use ... Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington ... Delta,s biometric boarding pass experience that ... integrated into the boarding process to allow eligible Delta SkyMiles Members who ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017  IBM ... in dairy research, today announced a new collaboration using ... the chances that the global milk supply is impacted ... project, Cornell University has become the newest academic institution ... Chain, a food safety initiative that includes IBM Research, ...
(Date:5/23/2017)... Italy , May 23, 2017  Hunova, the first robotic gym ... trunk, has been officially launched in Genoa, Italy . ... Europe and the USA . The technology ... on the market by the IIT spin-off Movendo Technology thanks to a ... the Multimedia News Release, please click: ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... States multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® ... identifying clinically significant acute bacterial and viral respiratory tract infections by testing ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and ... Labs ), Inc. has been selected for membership in ARCS Alumni Hall ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... it will be hosting a Webinar titled, “Pathology is going digital. Is your ... on digital pathology adoption best practices and how Proscia improves lab economics and ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
Breaking Biology Technology:
Cached News: